Compounds and methods for diagnosis of tuberculosis

Details Compounds and methods for diagnosis of tuberculosis Compounds and methods for diagnosis of tuberculosis

2006-10-17

2006-10-17

Swartz, Rodney P (Department: 1645)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

C424S130100, C424S139100, C424S150100, C424S184100, C424S185100, C424S234100, C435S006120, C530S300000, C530S350000, C536S023700

Reexamination Certificate

active

07122196

ABSTRACT:
Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or moreM. tuberculosisproteins, and DNA sequences encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection ofM. tuberculosisinfection in patients and biological samples. Antibodies directed against such polypeptides are also provided.

REFERENCES:
patent: 3943119 (1976-03-01), Tsumita et al.
patent: 5108745 (1992-04-01), Horwitz
patent: 419 355 (1991-03-01), None
patent: 519 218 (1992-12-01), None
patent: 2 244 539 (1975-05-01), None
patent: 2 265 402 (1975-11-01), None
patent: WO 88/05823 (1988-08-01), None
patent: WO 91/04272 (1991-04-01), None
patent: WO 91/14448 (1991-10-01), None
patent: WO 92/04049 (1992-03-01), None
patent: WO 92/14823 (1992-09-01), None
patent: WO 92/21758 (1992-12-01), None
patent: WO 94/00493 (1994-01-01), None
patent: WO 95/01440 (1995-01-01), None
patent: WO 95/01441 (1995-01-01), None
patent: WO 95/14713 (1995-06-01), None
patent: WO 95/31216 (1995-11-01), None
patent: WO 96/15241 (1996-05-01), None
patent: WO 96/23885 (1996-08-01), None
patent: WO 97/09428 (1997-03-01), None
patent: WO 97/09429 (1997-03-01), None
Andersen and Hansen, “Structure and mapping antigenic domains of protein antigen b, a 38,000-molecular-weight protein ofMycobacterium tuberculosis,” Infection and Immunity, vol. 37, No. 8; pp. 2481-2488 (1989).
Andersen et al., “Identficication of immunodominant antigens during infection withMycobacterium tuberculosis,” Scand. J. Immunol., vol. 36, pp. 823-831 (1992).
Andersen, P., “Effective vaccination of mice againstMycobacterium tuberculosis with a soluble mixture of secreted mycobacterial proteins,” Infection and Immunity, vol. 62, No. 6, pp. 2536-2544 (1994).
Ausebel et al., “Isolation of proteins for microsequence analysis,” in: Current Protocols in Molecular Biology, Wiley & Sons, New York, pp. 10.19.1-12 (1993).
Barnes et al., “Immunoreactivity of a 10-kDa antigen ofMycobacterium tuberculosis,” J. Immunol., vol. 148, No. 6; pp. 1835-1840 (1992).
Boesen et al., “Human T-cell responses to secreted antigen fractions ofMycobacterium tuberculosis,” Infection and Immunity, vol. 63, No. 4; pp. 1491-1497 (1995).
Borremans et al., “Cloning, sequencing determination, and expression of a 32-kilodalton-protein gene ofMycobacterium tuberculosis,” Infection and Immunity, vol. 57, No. 10; pp. 3123-3130 (1989).
Content et al., “The genes coding for antigen 85 complexes ofMycobacterium tuberculosisandMycobacterium bovisBCG are members of a gene family: Cloning, sequence determination, and genomic organization of the gene coding for antigen 85-C ofM. tuberculosis,” Infection and Immunity, vol. 59; pp. 3205-3212 (1991).
Horowitz, et al., “Protective immunity against tuberculosis induced by vaccination with major extracellular proteins ofMycobacterium tuberculosis,” PNAS USA, vol. 92; pp. 1530-1534 (1995).
Lowrie et al., “Towards a DNA vaccine against tuberculosis,” Vaccine, vol. 12, No. 16; pp. 1537-1540 (1994).
Matsumoto et al, “Cloning and sequencing of a unique antigen MPT70 fromMycobacterium tuberculosisH37Rv and expression in BCG usingE. coli-Mycobacteriashuttle vector,” Scand. J. Immunol., vol. 41, pp. 281-287 (1995).
Nagai et al., “Isolation and partial characterization of major protein antigens in the culture fluid ofMycobacterium tuberculosis,” Infection and Immunity, vol. 59, No. 1; pp. 372-382 (1991).
Oettinger and Andersen, “Cloning and B-cell-epitope mapping of MPT64 fromMycobacterium tuberculosisH37Rv,” Infection and Immunity, vol. 62, No. 5; pp. 2058-2064 (1994).
Pal and Horwitz, “Immunization with extracellular proteins ofMycobacterium tuberculosisinduces cell-mediated immune responses and substantial protective immunity in a guniea pig model of pulmonary tuberculosis,” Infection and Immunity, vol. 60, No. 11; pp. 4781-4792 (1992).
Romain et al., “Isolation of a proline-rich mycobacterial protein eliciting delayed-type hypersensitivity reactions only in guinea pigs immunized with living mycobacteria,” PNAS USA, vol. 90; pp. 5322-5326 (1993).
Wallis et al, “Identification of antigens ofMycobacterium tuberculsosisusing human monoclonal antibodies,” J. Clin. Invest., vol. 84; pp. 214-219 (1989).
Wiker and Harboe, “The antigen 85 complex: A major secretion product ofMycobacterium tuberculosis,” Microbiological Reviews, vol. 56, No. 4; pp. 648-661 (1992).
Yamaguchi et al., “Cloning and characterization of the gene for immunogenic protein MPB64 ofMycobacterium bovisBCG,” Infection and Immunity, vol. 57, No. 1; pp. 283-288 (1989).
Young et al., “Screening of a recombinant mycobacterial DNA library with polyclonal antiserum and molecular weight analysis of expressed antigens,” Infection and Immunity, vol. 55, No. 6; pp. 1421-1425 (1987).

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