Compounds and methods for diagnosis of leishmaniasis

Details Compounds and methods for diagnosis of leishmaniasis Compounds and methods for diagnosis of leishmaniasis

1995-04-21

1999-06-15

Minnifield, Nita

Chemistry: molecular biology and microbiology

Vector, per se

435 71, 435 722, 435 792, 435 795, 435975, 530300, 530326, 5303881, 5303871, 5303886, 5303879, 530810, 530822, C12N 1500, G01N 3353, C07K 500, C07K 1600

Patent

active

059121661

ABSTRACT:
Compounds and methods are provided for diagnosing Leishmania infection. Disclosed compounds include polypeptides that contain at least an epitope of the Leishmania chagasi acidic ribosomal antigen LcP0, or a variant thereof. Such compounds are useful in a variety of immunoassays for detecting Leishmania infection and for identifying individuals with asymptomatic infections that are likely to progress to acute visceral leishmaniasis. The polypeptide compounds are further useful in vaccines and pharmaceutical compositions for preventing leishmaniasis.

REFERENCES:
patent: 4992273 (1991-02-01), Monjour et al.
patent: 5304371 (1994-04-01), Reed
patent: 5411865 (1995-05-01), Reed
patent: 5719263 (1998-02-01), Reed
Skeiky et al., "Antigens Shared by Leishmania Species and Trypanosoma cruzi: Immunological Comparison of the Acidic Ribosomal P0 Proteins," Infection and Immunity 62(5): 1643-1651, (1994).
Burns, Jr. et al., "Molecular chaacterization of a kinesin-related antigen of Leishmania chagasi that detects specific antibody in African and American visceral leishmaniasis," Proc. Natl. Acad. Sci. USA 90: 775-779, 1993.
Skeiky et al., "Cloning and Expression of Trypanosoma cruzi Ribosomal Protein P0 and Epitode Analysis of Anti-P0 Autoantibodies in Chagas' Disease Patients," Journal of Experimental Medicine 176 : 201-211, 1992.
Soto et al., "Isolation, characterization and analysis of the expression of the Leishmania ribosomal PO protein genes," Molecular and Biomedical Parasitology 61: 265-274, 1993.
Soto et al., "Genomic Organization and Expression of Two Independent Gene Arrays Coding for Two Antigenic Acidic Ribosomal Proteins of Leishmania," Journal of Biological Chemistry 268(29): 21835-21843, 1993.
Jeronimo et al, Trans. Royal Soc. Trop. Med & Hyg. 88/4:386-388, 1994.
Vinhas et al, Brazilian J. Med. Biol. Res. 27:1199-1205, 1994.
White et al, Am. J. Trop. Med. Hyg. 46/2: 123-131, 1992.
Reed et al. 1987. J. Immunol. 138(5): 1596-601.
Reed et al. 1990. Am. J. Trop. Med. Hyg. 43(6):632-39.
Dillon et al. 1995, PNAS (USA). 92: 7981-85.
Bowie et al, Science, 247:1306-1310 1990.
Bixler et al. In. Synthetic Vaccines vol. 1:39-71 1987.

Affiliated with

Also associated with

Rating

Compounds and methods for diagnosis of leishmaniasis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compounds and methods for diagnosis of leishmaniasis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds and methods for diagnosis of leishmaniasis will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-402098