Compounds and method for the prevention and treatment of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Details

C514S002600, C514S009100, C514S015800, C514S016700, C514S017400, C530S300000, C530S317000, C530S324000, C530S409000

Reexamination Certificate

active

07115566

ABSTRACT:
The invention provides peptide derivatives designed to deliver peptides having growth factor inhibitory activity, especially somatostatin analogs, to the retina by sequential metabolism. The peptide derivatives, which comprise a dihydropyridine⇄pyridinium salt-type redox targetor moiety, a bulky lipophilic function and an amino acid/dipeptide/tripeptide spacer, are used in the prevention and treatment of diabetic retinopathy.

REFERENCES:
patent: 6440933 (2002-08-01), Bodor et al.
patent: WO 9912572 (1999-03-01), None

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