Compounds and hapten-immunoglobulin conjugates derived from them

Details Compounds and hapten-immunoglobulin conjugates derived from them Compounds and hapten-immunoglobulin conjugates derived from them

1983-12-05

1984-11-13

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424 85, C07G 700, A61K 39395

Patent

active

044824840

ABSTRACT:
Compounds of formula (I) ##STR1## in which n is 1 or 2, R.sup.1 is C.sub.1-4 alkyl, C.sub.1-4 alkoxy, nitro, amino, halo or hydroxy, m is 0, 1 or 2, R.sup.2 is an immunogenic determinant and x is 1 or 2, provided that when n is 1, x is 1 or 2 and there is one diazo moiety at the 3-position or two diazo moieties at the 3- and 5-positions, with respect to the isothiocyanate group, and the hydroxy group is at the 4-position; and provided that when n is 2, x is 1 and the diazo moiety is at the 4-position and the hydroxy groups are at the 3- and 5-positions, are described. The compounds are useful in the preparation of immunoglobulin conjugates for employment in diagnostic techniques.

REFERENCES:
patent: 3843447 (1974-10-01), Burkoth
patent: 3873697 (1975-03-01), Filipp et al.
patent: 4160763 (1979-07-01), Muller
Wofsy & Henry, Contemporary Topics in Molecular Immunology, 7, 215 (1978) Plenim Press.
Cammisuli & Wofsy, J. Immun., 117, 1695 (1976).

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