Compounds and compositions for reducing lipid levels

Details Compounds and compositions for reducing lipid levels Compounds and compositions for reducing lipid levels

2011-08-23

2011-08-23

Weddington, Kevin E (Department: 1629)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S071000, C546S072000, C546S125000

Reexamination Certificate

active

08003795

ABSTRACT:
Compositions comprising extracts or isolated or purified compounds from plants of the genusCorydalisprovide prevention and treatment of hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, hepatic steatosis, and metabolic syndrome.Corydaliscompounds and their derivatives of natural and synthetic origins lower total cholesterol, LDL-cholesterol, and triglycerides and increase hepatic LDL receptor expression and activate AMP-activated protein kinase. Specific stereoisomers ofCorydaliscompounds with lipid lowering activity include 14R-(+)-corypalmine, 14R,13S-(+)-corydaline, 14R-(+)-tetrahydropalmatin, (+)-corlumidin, d-(+)-bicuculline, and (+)-egenine.

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