Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-12-03
1995-12-12
Haley, Jacqueline
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548545, 548547, 548548, 548549, C07D207325, C07D207452, A61K 3140
Patent
active
054750210
ABSTRACT:
The present invention includes N-substituted maleimides (1(H)-Pyrrole-2,5-dione (Maleimide) analogs and succinimides which act as potent nonsteroidal anti-inflammatory drugs and are capable of dual inactivation or selective inactivation of the cyclooxygenase and the peroxidase activities of prostaglandin endoperoxide synthase (PGHS).
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Kalgutkar Amit S.
Marnett Lawrence J.
Haley Jacqueline
Taylor, Jr. Arles A.
Vanderbilt University
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