Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Reexamination Certificate
2005-12-06
2005-12-06
Zucker, Paul A. (Department: 1621)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
C562S455000
Reexamination Certificate
active
06972300
ABSTRACT:
Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides, such as rhGH. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration, are provided, and methods of preparation of the modified amino acid compound are provided.
REFERENCES:
patent: 3489793 (1970-01-01), Bertelli
patent: 3931153 (1976-01-01), Schmidt et al.
patent: 4613618 (1986-09-01), Choay et al.
patent: WO-94/23767 (1994-10-01), None
Milstein, Sam, “Oral Bioavailability of Partially Folded Proteins”, Proceedings of the 1995 Miami Bio/Technology Winter Symposium, Advances in Gene Technology: Protein Engineering and Structural Biology, Short Reports, vol. 6, Feb. 4-9, 1995, p. 13.
Ibrahim, El Sebai A., et al., “Synthesis of 4-Substituted Aminobenzoate Quaternary Salts asd Potent Antispasmodic Agents”, Journal of Pharmaceutical Sciences, American Pharmaceutical Association, vol. 68, No. 3, Mar. 1979, pp. 332-335.
Picciola, G., “Sintesi Di Acidi Chinazolinonici e Benzossazinocini e Studio Delle Loro Proprieta Antiinfiammatorie”, Farmaco, Edizione Scientifica, vol. 31, No. 9, 1976, pp. 655-664.
Jorgensen, Eugene C., et al., “Angiotensin II analogs. IV. Synthesis and Biological Evaluation of Simplified Angiotensins”, Journal of Medicinal Chemistry, vol. 13, No. 4, 1970, pp. 744-745.
Leone-Bay, Andrea, et al., “N-Acylated a-Amino Acids as Novel Oral Delivery Agents for Proteins”, Journal of Medicinal Chemistry, vol. 31, No. 21, 1995, pp. 4263-4269.
Ho Koc-Kan
Leone-Bay Andrea
Milstein Sam J.
Sarubbi Donald J.
Darby & Darby
Emisphere Technologies Inc.
Zucker Paul A.
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