Compounds and compositions derived from olives and methods...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Reexamination Certificate

active

06906100

ABSTRACT:
The preparation of extracts from olive fruits, olive tree leaves, olive oil as well as olive-press waste. The isolation of natural products from these extracts and the evaluation of the DNA protective antioxidant activity of the extracts and the purified compounds on intact cells.

REFERENCES:
patent: 6361803 (2002-03-01), Cuomo et al.
patent: 6416808 (2002-07-01), Crea
patent: 6455580 (2002-09-01), Fredrickson
patent: 2002/0004077 (2002-01-01), Cuomo et al.
patent: 0811678 (1997-12-01), None
patent: 2145701 (2000-07-01), None
patent: 8119825 (1996-05-01), None
patent: 2151137 (2000-06-01), None
patent: WO 02/16628 (2002-02-01), None
patent: WO 02/18310 (2002-03-01), None
Martindale, The Extra Pharmacopoeia, 28thedition, Published 1982 by The Pharmaceutical Press, (London) p. 697.
Barbouti, et al., 2000, “DNA Damage and Apoptosis in Hydrogen Peroxide-Exposed Jurkat Cells: Bolus Addition versus Continuous Generation of H2O2, ”Free Radical Biology&Medicine, 2002, pp. 691-702, vol. 33, No. 5.
De La Cruz, et al., May 2000, “Lipid Peroxidation and Glutathione System in Hyperlipemic Rabbits: Influenece of Olive Oil Administration,”Molecular and Cell Biology of Lipids, May 2000, pp. 36-44, vol. 1485, No. 1.
Johnson, et al., Apr. 28, 2000, “Effects of Epigallocatechin Gallate and Quercetin on Oxidative Damage to Cellular DNA,”Mutation Research, pp. 211-218, vol. 459, No. 3, Apr. 28, 2000.
Manna, et al., Mar. 2000, “Transport Mechanism and Metabolism of Olive Oil Hydroxytyrosol in Caco-2 Cells,”FEBS Letters, Mar. 2000, pp. 341-344, vol. 470, No. 3.
Deiana, et al., Mar. 1999, “Inhibition of Peroxynitrite Dependent DNA Base Modification and Tyrosine Nitration by the Extra Vigin Olive Oil-Derived Antioxidant Hydroxytyrosol,”Free Radical Biology&Medicine, Mar. 1999, pp. 762-769, vol. 26, Nos. 5/6.
Gil, et al., Nov. 1998, “Two Glutaric Acid Derivatives from Olives,”Phytochemistry, Nov. 1998, pp. 1311-1315, vol. 49, No. 5.
Visioli, et al., 1995, “Waste waters' from Olive Oil Production are Rich in Natural Antioxidants,”Experientia, 1995, pp. 32-34, vol. 51.
Ford, et al., 1972, “Preparation of Calcium Elenolate from Olive Press Juice,”Organic Preparations and Procedures, 1972, pp. 97-104, vol. 4, No. 2.
N/A English Translation of Abstract to RU 2151137, as listed above under Reference, Jun. 20, 2000.
N/A English Translation of Abstract to JP 8119825, as listed above under Reference, May 14, 1996.

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