Compounds and compositions as protein kinase inhibitors

Details Compounds and compositions as protein kinase inhibitors Compounds and compositions as protein kinase inhibitors

2008-09-09

2008-09-09

Kifle, Bruck (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C540S522000

Reexamination Certificate

active

10836030

ABSTRACT:
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases and disorders associated with kinase activity, particularly diseases associated with the activity of CDK1, CDK2, CDK4, CDK5, GSK3β, Bcr-ab1, Flt-3, c-Kit, PDGFRβ, Src, Mek1 and CK1.

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Xu, Ying-zi, et al. Synthesis of C11N5 Marine Sponge Alkaloids: -Hymenin, Stevensine, Hymenialdisine, and Debromohymenialdisine, J. Org. Chem., 1997, vol. 62, pp. 456-464.
Chacun-Lefevre, Lidwine. Intramolecular Heck Coupling of Alkenyl 3-Iodoindole-2-carboxamide Derivatives, Synlett 2001, No. 6, pp. 848-850.
Annoura, H., et al. Total Syntheses of Hymenialdisine and Debromohymenialdisine: Stereospecific Construction of the 2-Amino-4-Oxo-2-Imidazolin-5(Z)-Disubstituted Ylidene Ring System, Tetrahedron Letters, 1995, vol. 36, No. 3, pp. 413-416.

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