Compounds and compositions as protein kinase inhibitors

Details Compounds and compositions as protein kinase inhibitors Compounds and compositions as protein kinase inhibitors

2008-05-13

2008-05-13

Berch, Mark L (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S242000, C514S252160, C514S262100, C544S112000, C544S118000, C544S182000, C544S256000, C544S279000, C544S081000

Reexamination Certificate

active

10909227

ABSTRACT:
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, Bmx, c-Raf, Csk, Fes, FGFR, Flt3, Ikk, IR, JNK, Lck, Mkk, PKC, PKD, Rsk, SAPK, Syk, Trk, BTK, Src, EGFR, IGF, Mek, Ros and Tie2 kinases.

REFERENCES:
patent: 6150373 (2000-11-01), Harris et al.
patent: 7112676 (2006-09-01), Dermatakis et al.
patent: 2004/0019210 (2004-01-01), Chivikas Connolly et al.
patent: 2004/0087600 (2004-05-01), Cai et al.
patent: 2004/0204427 (2004-10-01), Chen et al.
patent: 2007/0232611 (2007-10-01), Engh et al.
patent: WO 99/61444 (1999-12-01), None
patent: WO 00/24744 (2000-05-01), None
patent: WO 01/29042 (2001-04-01), None
patent: WO 2004/041821 (2004-05-01), None
Background Information for the Oct. 2002 ACPS Meeting.
Wikipedia (Isomer), 2007.
Souillac, et al., Characterization of Delivery Systems, Differential Scanning Calorimetry, p. 217 (in Encyclopedia of Controlled Drug Delivery, 1999, John Wiley & Sons, pp. 212-227).
Goldman, et al., N. England J. Med., 344, 14, Apr. 5, 2001.
Ekman, et al., Oncogene (2000) 19, 4151-58.
Xu, et al., J. Biol. Chem., 273, 50, Dec. 11, 1998. 33230-38.
Zhang, et al., J. Biol. Chem., vol. 279, No. 53, Dec. 31, 2004, pp. 55348-55354.
Lopes de Menezes, et al., Clin. Cancer Res. 2005:11 (14), Jul. 15, 2005, 5281-91.
Kawahara, et al., J. Clin. Onc., 2006 ASCO Annual Meeting Proceedings, Part I, vol. 27, No. 18S, Jun. 20, 2006, 13163.
Yoshida, et al., J Neurochem., 2004, 90, 352-58.
Atlas of Genetics & Cytogenetics in Oncology & Haematology (Sep. 12, 2007) LCK.
Brandlin, et al., J. Biol. Chem., vol. 277, No. 8, Feb. 22, 2002; 6490-6496.
Wu, et al., Am. J. Pathol., 156, Jun. 6, 2000.
Khan, et al., Journal of Allergy and Clinical Immunology, vol. 119, Issue 5, Mar. 6, 2007, p. 1277.
Webster's Comprehensive Dictionary, 1996, “prevent.”
Graveleau, Nadege et al. Solid-Phase Synthesis of Pyrimido [4,5-d] pyrimidine-2,4(1H,3H)-diones. Synthesis May 8, 2003, No. 11, pp. 1739-1743.

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