Compounds and compositions as protein kinase inhibitors

Details Compounds and compositions as protein kinase inhibitors Compounds and compositions as protein kinase inhibitors

2011-01-11

2011-01-11

Wilson, James O (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S122000, C546S083000, C544S279000, C544S117000, C514S264100, C514S264110, C514S234200, C514S293000

Reexamination Certificate

active

07868018

ABSTRACT:
The invention provides compounds of Formula I:wherein R1-R6are described in the Summary of the Invention; the pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, BMX, BTK, CHK2, b-RAF, c-RAF, CSK, c-SRC, Fes, FGFR3, Flt3, IKKα, IKKβ, JNK2α2, Lck, Met, MKK4, MKK6, MST2, NEK2, p70S6K, PDGFRβ, PKA, PKBα, PKD2, Rsk1, SAPK2α, SAPK2β, SAPK3, SGK, Tie2 and TrkB kinases.

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Wikipedia, Kinase, http://en.wikipedia.org/wiki/Kinase, May 5, 2010.
Connolly, CJC et al., “Discovery and structure-activity studies of a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors”, Bioorganic and Medicinal Chemistry Letters, Sep. 23, 1997, pp. 2415-2420, vol. 7, No. 18.
Hamby, JM et al., “Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors”, Journal of Medicinal Chemistry, 1997, pp. 2296-2303, vol. 40, No. 15.

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