Compounds and compositions as anticoagulants

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

514396, 5462734, 5483074, 558300, A61K 314184, A61K 314439, C07D23518, C07D40104

Patent

active

061503797

ABSTRACT:
The present invention relates to novel biheterocyclic derivatives which are factor Xa inhibitors; the pharmaceutically acceptable salts and N-oxides thereof; their uses as therapeutic agents and the methods of their making.

REFERENCES:
patent: 3105837 (1963-10-01), Ursprung
patent: 3210370 (1965-10-01), Ursprung
patent: 3324050 (1967-06-01), Joo et al.
patent: 4074046 (1978-02-01), Mohan
patent: 4940723 (1990-07-01), Tidwell et al.
patent: 5126352 (1992-06-01), Ganguly et al.
patent: 5428051 (1995-06-01), Tidwell et al.
patent: 5552426 (1996-09-01), Lunn et al.
patent: 5693515 (1997-12-01), Clark et al.
patent: 5900371 (1999-05-01), Clark et al.
Nagahara et al., "Dibasic (Amidinoaryl) propanoic Acid Derivatives as Novel Blood Coagulation Factor Xa Inhibitors," J. Med. Chem. 37:1200-1207 (1994).
Katz et al., "Design of potent selective zinc-mediated serine protease inhibitors," Nature 39:608-612 (1998).
Caughey et al., "Bis (5-Amidino-2-Benzimidazolyl) Methane and Related Amidines Are Potent, Reversible Inhibitors of Mast Cell Tryptases," J. Pharmacol. Exp. Ther. 264: 676-682 (1993).
Fairley et al., "Structure, DNA Minor Groove Binding, and Base Pair Specificity of Alkyl- and Aryl-Linked Bis (amidinobenzimidazoles) and Bis (amidinoindoles)," J. Med. Chem. 36: 1746-1753 (1993).
Geratz et al., "Streptococcal Cell Wall-Induced Systematic Disease," American Journal of Pathology 139 (4): 921-931 (1991).
Tidwell et al., "Aromatic Amidines: Comparison of Their Ability to Block Respiratory Syncytial Virus Induced Cell Fusion and to Inhibit Plasmin, Urokinase, Thrombin, and Trypsin," J. Med. Chem. 26: 294-298 (1983).
Tidwell et al. , "Diarylamadine Derivatives with One or Both of the Aryl Moieties Consisting of an Indole or Indole-like Ring. Inhibitors or Arginine-Specific Esteroproteases" J. Med. Chem. 21 (7): 613-623 (1978).
Tidwell et al., "Suppression of Respiratory Syncytial Virus Infection in Cotton Rats by Bis (5-Amidino-2-Benzimidazolyl) Methane," Antimicrobial Agents and Chemotherapy 26:591-593 (1984).

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