Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1999-02-18
2000-04-18
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
564315, A61K 31135, C07C21135
Patent
active
060516100
ABSTRACT:
Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, epilepsy, anxiety, or neurodegenerative diseases such as Alzheimer's Disease, Huntington's Disease, Parkinson's Disease, or amyotrophic lateral sclerosis (ALS).
REFERENCES:
patent: 2894033 (1959-07-01), Janssen et al.
patent: 3238242 (1966-03-01), Harsanyi et al.
patent: 3372193 (1968-03-01), Moffett et al.
patent: 4018895 (1977-04-01), Molloy et al.
patent: 4028415 (1977-06-01), Clark
patent: 4313896 (1982-02-01), Molloy et al.
patent: 4988730 (1991-01-01), Korbonits et al.
patent: 5037846 (1991-08-01), Saccomano et al.
patent: 5145870 (1992-09-01), Jakobsen et al.
patent: 5185369 (1993-02-01), Saccomano et al.
patent: 5310756 (1994-05-01), Jakobsen et al.
patent: 5382600 (1995-01-01), Jonsson et al.
Akaike et al., "Spider Toxin Blocks Excitatory Amino Acid Responses in Isolated Hippocampal Pyramidal Neurons," Neuroscience Letters 79:326-330 (1987).
Anis et al., "Structure-Activity Relationships of Philanthotoxin Analogs and Polyamines on N-Methyl-D-Aspartate and Nicotinic Acetylcholine Receptors," Journal of Pharmacology and Experimental Therapeutics 254:764-773 (1990).
Artman et al., "Preferential Inhibitory Effects of Arylamine Spider Toxins on NMDA Receptor-Mediated Increases in Cytosolic Calcium," Society for Neuroscience Abstracts 17(Part 1):394 at abstract No. 163.19 (1991).
Ashe et al., "Argiotoxin-636 Blocks Excitatory Synaptic Transmission in Rat Hippocampal CA1 Pyramidal Neurons," Brain Research 480:234-240 (1989).
Beckett and Casy, "Configurational Studies in Synthetic Analgesics," J. Chem. Soc. pp. 900-904 (1955).
Blagbrough and Usherwood, "Polyamine amide toxins as pharmacological tools and pharmaceutical agents," Proceedings of the Royal Society of Edinburgh 99B(1-2):67-81 (1992).
Blagbrough et al., "Arthropod Toxins as Leads for Novel Insecticides: An Assessment of Polyamine Amides as Glutamate Antagonists," Toxicon 30:303-322 (1992).
Blake et al., "2-Methyl-3,3-Diphenyl-3-Propanolamine (2-MDP) Selectively Antagonises N-Methyl-Aspartate (NMA)," Pharmacology Biochemistry & Behavior 24:23-25 (1986).
Blaschke et al., "A Single Amino Acid Determines the Subunit-Specific Spider Toxin Block of Amino-3-Hydroxy-5-Methylisoxazole-4-Propionate/Kainate Receptor Channels," Proc. Natl. Acad. Sci. USA 90:6528-6532 (1993).
Brackley et al., "Selective Antagonism of Native and Cloned Kainate and NMDA Receptors by Polyamine-Containing Toxins," Journal of Pharmacology and Experimental Therapeutics 266:1573-1580 (1993).
Bruce et al., "Structure-Activity Relationships of Analogues of The WASP Toxin Philanthotoxin: Non-Competetive Antagonists of Quisqualate Receptors," Toxicon 28(11):1333-1346 (1990).
Burtsev and Savkov, "Calcium Antagonists (Finoptin and Senzit) in the Treatment of Cerebrovascular Disorders," Klinicheskaia Meditsina 67(9):51-54 (1989) (abstract from Medline).
Buschauer et al., "Synthesis and histamine H.sub.2 agonistic activity of arpromidine analogues: replacement of the pheniramine-like moiety by non-heterocyclic groups," Eur. J. Med. Chem. 27:321-330 (1992).
Camps et al., "A New and Efficient One-Pot Preparation of Alkyl Halides From Alcohols," Synthesis Communications pp. 511-512 (May 1987).
Chemical Abstracts 5:423 (1911).
Chemical Abstracts 54:24555i (1960), 24555-24556.
Chemical Abstracts 54:424a (1960).
Chemical Abstracts 66:4375 (1967).
Chemical Abstracts 67:3059 (1967).
Chemical Abstracts 69:3322 (1968).
Chemical Abstracts Service, Registry Handbook Reg. No. 114272-62-7 through 116231-28-8, 1988 Supplement.
Choi et al., "Glutamate Neurotoxicity in Cortical Cell Culture," J. Neuroscience 7:357-368 (1987).
Choi et al., "Synthesis and Assay of Hybrid Analogs of Argiotoxin-636 and Philanthotoxin-433: Glutamate Receptor Antagonists," Tetrahedron 49:5777-5790 (1993).
Choi, "Glutamate Neurotoxicity and Diseases of the Nervous System," Neuron 1:623-634 (1988).
Collingridge and Davis, "Ch. 9--NMDA receptors and long-term potentiation in the hippocampus," in The NMDA Receptor, edited by Watkins and Collingridge, IRL Press, pp. 123-135 (1989).
Cramer et al., "Kainic Acid and 4-Aminopyridine Seizure Models in Mice: Evaluation of Efficacy of Anti-Epileptic Agents and Calcium Antagonists," Life Sciences 54:PL271-PL275 (1994).
Davies et al., "Polyamine Spider Toxins Are Potent Un-competitive Antagonists of Rat Cortex Excitatory Amino Acid Receptors," European Journal of Pharmacology--Molecular Pharmacology Section 227:51-56 (1992).
Deneris et al., "Pharmacological and Functional Diversity of Neuronal Nicotinic Acetylcholine Receptors," TiPS 12:34-40 (1991).
Dickenson, "A Cure for Wind-Up: NMDA Receptor Antagonists as Potential Analgesics," TiPS 11:307-309 (1990).
Dingledine et al., "Excitatory Amino Acid Receptors in Epilepsy," TiPS 11:334-338 (1990).
Donevan and Rogawski, "GYKI 52466, a 2,3-Benzodiazepine, is a Highly Selective, Noncompetitive Antagonist of AMPA/Kainate Receptor Responses," Neuron 10:51-59 (1993).
Donevan et al., "Arcaine Blocks N-Methyl-D-Aspartate Receptor Responses by an Open Channel Mechanism: Whole-Cell and Single-Channel Recording Studies in Cultured Hippocampal Neurons," Molecular Pharmacology 41:727-735 (1992).
Draguhn et al., "Argiotoxin.sub.636 inhibits NMDA-activated ion channels expressed in Xenopus oocytes," Neuroscience Letters 132:187-190 (1991).
Fiedler et al., "66. Synthetische Analoga von niedermolekularen Spinnentoxinen mit Acyl-polyamin-Struktur," Helvetica Chimica Acta 76:1167-1181 (1993).
Fiedler et al., "98. Synthese von selektiv N-funktionalisierten Polyamin-Derivaten," Helvetica Chimica Acta 76:1511-1519 (1993).
Fingl and Woodbury, "Chapter 1--General Principles," in The Pharmacological Basis of Therapeutics 5th edition, Goodman and Gilman editors, MacMillan Publishing Co., Inc., New York, pp. 1-46 (1975).
Fisher and Bogousslavsky, "Evolving Toward Effective Therapy for Acute Ischemic Stroke," JAMA 270:360-364 (1993).
Foye et al., Principals of Medicinal Chemistry, 4th edition, Lea & Febiger/Williams and Wilkins, Philadelphia, PA, pp. 233, 265, 281-282, 340-341, 418-427 and 430 (1995).
Ginsberg and Busto, "Rodent Models of Cerebral Ischemia," Stroke 20:1627-1642 (1989).
Gisvold and Steen, "Drug Therapy in Brain Ischaemia," Br. J. Anaesth. 57:96-109 (1985).
Grishin et al., "Isolation and Structure Analysis of Components from Venom of the Spider Argiope lobata," Toxicon 27:451-549 (1989).
Gullak et al., "CNS Binding Sites of the Novel NMDA Antagonist Arg-636," Soc. Neurosci. Abst. 15:1168 at abstract No. 463.23 (1989).
Hayes et al., "Anticonvulsant Properties of Phencyclidine-Like Drugs in Mice," European Journal of Pharmacology 117:121-125 (1985).
Helke and Raines, "Antiextensor Effects of 3,3-Diphenyl-n-Propylamine in the Mouse," European Journal of Pharmacology 48:231-235 (1978).
Herlitze et al., "Argiotoxin Detects Molecular Differences in AMPA Receptor Channels," Neuron 10:1131-1140 (1993).
Herold and Yaksh, "Anesthesia and Muscle Relaxation with Intrathecal Injections of AR636 and AG489, Two Acylpolyamine Spider Toxins, in Rat," Anesthesiology 77:507-512 (1992).
Honore et al., "Quinoxalinediones: Potent Competitive Non-NMDA Glutamate Receptor Antagonists," Science 241:701-703 (1988).
Hughes, "Merz Novel Approach to the Treatment of Dementia," Script No. 1666:24-25 (1991).
Jackson and Parks, "Spider Toxins: Recent Applications In Neurobiology," Ann. Rev. Neurosci. 12:405-414 (1989).
Jackson and Usherwood, "Spider Toxins as Tools for Dissecting Elements of Excitatory Amino Acid Transmission," TINS 11:278-283 (1988).
Janssen et al., Synthetic Analgesics: Part I--Diphenylpropylamines, Pergamon Press, pp. 1-109 (1960).
Jasys et al., "Isolation, Structure Elucidation, and Synthesis of Novel Hydroxylamine-Containing Polyamines From the Venom of the Agelenopsis aperta Spider," J. Amer. Chem. Soc. 112:6696-6704 (1990).
Jasys et al., "The Total Synthesis of Argiotoxins 636, 659 and 673," Tetrahedron Letters 29:6223-6226 (1988).
Jones and Lodge, "Comparison of Some Arthropod Toxins and Toxin Frag
Artman Linda D.
Balandrin Manuel F.
Barmore Robert M.
DelMar Eric G.
Moe Scott T.
NPS Pharmaceuticals Inc.
Raymond Richard L.
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