Compounds active at a novel site on receptor-operated calcium ch

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

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514651, 564341, 564353, A61K 31135, C07C21762

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active

060179651

ABSTRACT:
Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, spinal cord ischemia, ischemia- or hypoxia-induced nerve cell damage, epilepsy, anxiety, neuropsychiatric or cognitive deficits due to ischemia or hypoxia such as those that frequently occur as a consequence of cardiac surgery under cardiopulmonary bypass, or neurodegenerative diseases such as Alzheimer's Disease, Huntington's Disease, Parkinson's Disease, or amyotrophic lateral sclerosis (ALS).

REFERENCES:
patent: 3372193 (1968-03-01), Moffett et al.
patent: 4018895 (1977-04-01), Molloy et al.
patent: 4194009 (1980-03-01), Molloy et al.
patent: 4313896 (1982-02-01), Molloy et al.
patent: 4314081 (1982-02-01), Molloy et al.
patent: 4626549 (1986-12-01), Molloy et al.
patent: 5037846 (1991-08-01), Saccomano et al.
patent: 5145870 (1992-09-01), Jakobsen et al.
patent: 5185369 (1993-02-01), Saccomano et al.
patent: 5281624 (1994-01-01), Gehlert et al.
patent: 5310756 (1994-05-01), Jakobsen et al.
Yoshida et al., chemical Abstracts, vol. 80, abstract 55671, 1974.
Ogawa et al., Chemical Abstracrs, vol. 87, abstract 5817, 1977.
Mirek et al., Chemical Abstracts, vol. 104, abstract 14845, 1986.
Akaike et al., "Spider Toxin Blocks Excitatory Amino Acid Responses in Isolated Hippocampal Pyramidal Neurons," Neurosci. Lett. 79:326 (1987).
Anis et al., Structure-Activity Relationships of Philanthotoxin Analogs and Polyamines on N-Methyl-D-Aspartate and Nicotinic Acetylcholine Receptors, Journal of Pharmacology and Experimental Therapeutics 254:764 (1990).
Artman et al., "Preferential Inhibitory Effects of Arylamine Spider Toxins on NMDA Receptor-Mediated Increases in Cytosolic Calcium," Society for Neuroscience Abstracts 17(1-2):394 (1991).
Ashe et al., "Argiotoxin-636 Blocks Excitatory Synaptic Transmission in Rat Hippocampal CA1 Pyramidal Neurons," Brain Res. 480: 234 (1989).
Beckett et al., "Configurational Studies in Synthetic Analgesics," J. Chem. Soc. 900 (1955).
Blagbrough et al., "Arthropod Toxins as Leads for Novel Insecticides: An Assessment of Polyamine Amides as Glutamate Antagonists," Toxicon 30:303 (1992).
Blagbrough et al., "Polyamine Amide Toxins as Pharmacological Tools and Pharmaceutical Agents," Proceedings of the Royal Society of Edinburg 99(1-2):67-81 (1992).
Blake et al., "2-Methyl-3, 3-Diphenyl-3-Propanolamine (2-MDP) Selectively Antagonises N-Methyl-Aspartate (NMDA)," Pharmacology Biochemistry & Behavior 24(1):23-25 (1986).
Blaschke et al., "A Single Amino Acid Determines the Subunit-Specific Spider Toxin Block of .alpha.-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionate/Kainate Receptor Channels," Proc. Natl. Acad. Sci. USA 90:6528 (1993).
Brackley et al., "Selective Antagonism of Native and Cloned Kainate and NMDA Receptors by Polyamine-Containing Toxins," J. Pharmacol. Exp. Therap. 266:1573 (1993).
Bruce et al., "Structure-Activity Relationships of Analogues of the Wasp Toxin Philanthotoxin: Non-Competitive Antagonists of Quisqualate Receptor," Toxicon 28:1333 (1990).
Buschauer et al., "Synthesis and Histamine H2 agonistic activity of arpromidine Analogues: Replacement of the Pheniramine-like Moiety by Non-Heterocyclic Groups," Eur. J. Med. Chem. 27:321-330 (1992).
Burtsev and Savkov, "Calcium Antagonists (Finoptin and Senzit) in the Treatment of Cerebrovascular Disorders," Klinicheskaia Meditsina 67(9):51-54 (1989) (abstract from MEDLINE).
Camps et al., "New and Efficient One-Pot Preparation of Alkyl Halides From Alcohols," Communications pp. 511-512 (May 1987).
Chemical Abstracts Service, Registry Handbook, Reg. No. 114272-62-7 through 116231-28-8, 1988 Supplement.
Chemical Abstracts 66:4375 (1967).
Chemical Abstracts 67:3059 (1967).
Chemical Abstracts 69:3322 (1968).
Chemical Abstracts 54:424a (1960).
Chemical Abstracts 5:423 (1959).
Chemical Abstracts 54:24555i (1960), 24555-24556.
Cheng and Prusoff, "Relationship Between the Inhibition Constant (K.sub.l) and the Concentration of Inhibitor Which Causes 50 Per Cent Inhibition (I.sub.50) of an Enzymatic Reaction," Biochemical Pharmacology 22:3099-3108 (1973).
Choi et al., "Synthesis and Assay of Hybrid Analogs of Argiotoxin-636 and Philanthotoxin-433: Glutamate Receptor Antagonists," Tetrahedron 49:5777 (1993).
Choi, "Glutamate Neurotoxicity and Diseases of the Nervous System," Neuron 1:623 (1988).
Choi et al., "Glutamate Neurotoxicity in Cortical Cell Culture," J. Neurosci. 7:357 (1987).
Collingridge and Davis, in The NMDA Receptor, IRL Press. p. 123 (1989).
Cramer et al., "Kainic Acid and 4-Aminopyridine Seizure Models in Mice: Evaluation of Efficacy of Anti-Epileptic Agents and Calcium Antagonists," Life Sciences 54:271-275 (1994).
Davies et al., "Polyamine Spider Toxins Are Potent Uncompetitive Antagonists of Rat Cortex Excitatory Amino Acid Receptors," European Journal of Pharmacology 227:51 (1992).
Deneris et al., "Pharmacological and Functional Diversity of Neuronal Nicotinic Acetylcholine Receptors," Trends Pharmacol. Sci. 12:34 (1991).
Dickenson, "A Cure for Wind-Up: NMDA Receptor Antagonists as Potential Analgesics," Trends Pharmacol. Sci. 11:307 (1990).
Dingledine et al., "Excitatory Amino Acid Receptors in Epilepsy," Trends Pharmacol. Sci. 11:334 (1990).
Donevan and Rogawski, "GYKI 52466, a 2,3-Benzodiazepine, is a Highly Selective, Noncompetitive Antagonist of AMPA/Kainate Receptor Responses," Neuron 10:51 (1993).
Donevan et al., "Arcaine Blocks N-Methyl-D-Aspartate Receptor Responses by an Open Channel Mechanism: Whole-Cell and Single-Channel Recording Studies in Cultured Hippocampal Neurons," Molec. Pharamcol. 41:727 (1992).
Draguhn et al., "Argiotoxin-636 Inhibits NMDA-Activated Ion Channels Expressed in Xenopus Oocytes," Neuroscience Letters 132(2):187-190 (1991).
Fiedler and Hesse, "Synthese von Selektiv N-funktionalisierten Polyamin-Derivaten, (Synthesis of Selectively N-Functionalized Polyamine Derivatives," Helvetica Chimica Acta 76:1511 (1993) [No English Translation].
Fiedler et al., "Synthetische Analoga von Niedermolekularen Spinnentoxinen mit Acyl-Polyamin-Stuktur," (Synthetic Analogues of Low-Molecular-Weight Acyl-Polyamine Spider Toxin), Helvetica Chimica Acta 76:1167 (1993) [No English Translation].
Fingl and Woodbury, Chapter 1, pp. 1-46 in The Pharmacological Basis of Therapeutics (5th edition),eds. Goodman et al., MacMillan Publishing Co., Inc., New York (1975).
Fisher and Bogousslavsky, "Evolving Toward Effective Therapy for Acute Ischemic Stroke," JAMA 270:360 (1993).
Foye et al., Principals of Medicinal Chemistry, 4th edition, Lea & Febiger/Williams and Wilkins, Philadelphia, PA, pp. 233, 265, 281-282, 340-341, 418-427 and 430 (1995).
Ginsberg and Busto, "Rodent Models of Cerebral Ischemia," Stroke 20:1627 (1989).
Gisvold et al., "Drug Therapy in Brain Eschaemia," British Journal of Anesthesia 57(1):96-109 (1985).
Grishin, "Isolation and Structure Analysis of Components from Venom of the Spider Argiope Lobata," Toxicon 27:451-549 (1989).
Gullak et al., "CNS Binding Sites of the Novel NMDA Antagonist Arg-636," Soc. Neurosci. Abst. 15:1168 (1989).
Hayes et al., "Anticovulsant Propeties of Phencyclidine-Like Drugs in Mice," European Journal of Pharmacology 117:121-125 (1985).
Helke et al, "Antiextensor Effects of 3,3-Diphenyl-n-Propylamine in Mouse," European Journal of Pharmacology 48(3):231-235 (1978).
Herlitz et al., "Argiotoxin Detects Molecular Differences in AMPA Receptor Channels," Neuron 10:1131 (1993).
Herold and Yaksh, "Anesthesia and Muscle Relaxation with Intrathecal Injections of AR636 and AG489, Two Acylpolyamine Spider Toxins, in Rats," Anesthesiology 77:507 (1992).
Hill, "A New Mathematical Treatment of Changes of Ionic Concentration in Muscle and Nerve Under the Action of Electric Currents, with a Theory as to Their Mode of Excitation," Journal of Physiology 40:190-224 (1910).
Honore et al., "Quinoxalinediones: Potent Competitive Non-NMDA Glutamate Receptor Antagonists," Science 241:701 (1988).
Hughes, "Merz' Novel Approach to the Treatment of Dementia," Script No. 1666:24 (1991).
Jackson and Parks, "Spider Toxins: Recent Applic

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