Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1995-06-07
2000-06-06
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514183, 514210, 514212, 514315, 514408, 514428, 514645, 514646, 514653, 514654, 564315, 564316, 564319, A61K 31135, C07C21103
Patent
active
060719702
ABSTRACT:
Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, epilepsy, anxiety, or neurodegenerative diseases such as Alzheimer's Disease, Huntington's Disease, Parkinson's Disease, or amyotrophic lateral sclerosis (ALS).
REFERENCES:
patent: 3372193 (1968-03-01), Moffett et al.
patent: 4018895 (1977-04-01), Molloy et al.
patent: 4313896 (1982-02-01), Molloy et al.
patent: 5037846 (1991-08-01), Saccomano et al.
patent: 5145870 (1992-09-01), Jakobsen et al.
patent: 5185369 (1993-02-01), Saccomano et al.
patent: 5310756 (1994-05-01), Jakobsen et al.
Marcusson, Jan O., et al., "Inhibition of [.sup.3 H]paroxetine binding by various serotonin uptake inhibitors: structure activity-relationships", European Journal of Pharmacology, 215, 1992, 191-198.
Chemical Abstracts, vol. 69, 1968, p. 3322.
Chemical Abstracts, vol. 67, 1967, p. 3059.
Chemical Abstracts, vol. 66, 1967, p. 4375.
Chemical Abstracts, vol. 5, p. 423, 1959.
Williams, Ifenprodil Discriminates Subtypes of the N-methyl-D-asparate Receptor: Selectivity and Mechanisms at Recombinant Heteromeric Receptors, Mol. Pharmacol., 44: 851, 1993).
Wiley and Balster, Preclinical Evaluation of N-Methyl-D-aspartate Antagonists for Antianxiety Effects: a Review In: Multiple Sigma and PCP Receptor Ligands; Mechanisms for Neuromodulation and Neuroprotection NPP Books, Ann Arbor, Michigan pp. 801-815, 1992.
Ginsberg and Busto, Rodent Models of Cerebral Ischemia, Stroke, 20:1627, 1989.
Karpiak et al., "Animal Models for the Study of Drugs in Ischemic Stroke", Ann. Rev. Pharmacol. Toxicol, 29:403, 1989.
Willetts et al., "The Behavioral Pharmacology of NMDA Receptor Antagonists" Trends Pharmacol. Sci., 11:423, 1990.
Olney, et al., "Pathological Changes Induced in Cerebrocortical Neurons by Phencyclidine and Related Drugs", Science, 244: 1360, 1989.
Snell and Johnson, "In: Excitatory Amino Acids in Health and Disease", John Wiley and Sons, p. 261, 1988.
Collingridge and Davis, In: The NMDA Receptor, IRL Press. p. 123, 1989.
Rogawski, "Therapeutic Potential of Excitatory Amino Acid Antagonists: Channel Blockers and 2,3-benzodiazepines", Trends Pharmacol. Sci., 14:325, 1993.
Nason, et al., "Synthesis of Neurotoxic Nephila Spider Venoms: NSTX-3 and JSTX-3", Tetrahedron Lett., 30:2337, 1989.
Scatton et al., "NMDA Receptor Antagonists: Treatment for Brain Ischemia," Drug News & Perspectives 4(2):89-95 (1991).
Burtsev and Savkov, "Calcium Antagonists (Finoptin and Senzit) in the Treatment of Cerebrovascular Disorders," Klinicheskaia Meditsina 67(9):51-54 (1989) (abstract from Medline).
Cramer et al., "Kainic Acid and 4-Aminopyridine Seizure Models in Mice: Evaluation of Efficacy of Anti-Epileptic Agents and Calcium Antagonists," Life Sciences 54:271-275 (1994).
Fingl and Woodbury, Chapter 1, pp. 1-46 in The Pharmacological Basis of Therapeutics (5th edition),eds. Goodman et al., MacMillan Publishing Co., Inc., New York (1975).
Foye et al., Principals of Medicinal Chemistry, 4th edition, Lea & Febiger/Williams and Wilkins, Philadelphia, PA, pp. 233, 265, 281-282, 340-341, 418-427 and 430 (1995).
Melloni et al., "Potential antidepressant agents. .alpha.-Aryloxy-benzyl derivatives of ethanolamine and morpholine," Eur. J. Med. Chem.--Chim. Ther. 19:235-242 (1984).
The Merck Index, 11th edition, Merck & Co., Inc., Rahway, New Jersey, p. 218 at No. 1433, p. 337 at No. 2180, p. 623 at No. 3916, p. 655 at No. 4112, p. 1148 at No. 7198, p. 1227 at No. 7744, p. 1444 at No. 9098, and p. 1597 at No. 10024 (1989).
Mikio et al., "Synthesis of Analgesics," Chemical Abstracts, vol. 83, No. 7, Aug. 18, 1975 at abstract No. XP002016632.
Palmer et al., "Anticonvulsant Properties of Calcium Channel Blockers in Mice: N-Methyl-D-, L-Aspartate- and Bay K 8644 Induced Convulsions are Potentially Blocked by the Dihydropyridines," Epilepsia 34:372-380 (1993).
Paul et al., "Adaptation of the N-Methyl-D-Aspartate Receptor Complex Following Chronic Antidepressant Treatments," J. Pharmacology and Experimental Therapeutics 269:95-102 (1994).
Prous, The Year'Drug News, Therapeutic Targets, 1995 Edition, Prous Science Publishers, Barcelona, Spain, pp. 13, 55-56, 58-59, 74, 89, 144-145, 152, 296-297 and 317 (1995).
Scatchard, "The Attractions of Proteins For Small Molecules and Ions," Ann. N.Y. Acad. Sci. 51:660-672 (1949).
Williams, "Effects of Agelenopsis Aperta Toxins on the N-Methyl-D-Aspartate Receptor: Polamine-Like and High-Affinity Antagonists Actions," J. Pharmacol. Exp. Therap. 266:231 (1993).
Chemical Abstracts Service, Registry Handbook, Reg. No. 114272-62-7 through 116231-28-8,(1988)Supplement.
Chemical Abstract 54:24555i (1960), 24555-245556.
Chemical Abstract 54:424a (1960).
Sutton, K.G., et al. "Inhibition of Voltage-Activated CA2+ Currents from Cultured Sensory Neurones By Spermine, Argiotoxin-636 and a Synthetic Arginine Polyamine" Molecular Neuropharmacology, vol. 3, 1993, pp. 37-43.
Blagbrough, I.S., et al., "Polyamine Amide Toxins as Pharmacological Tools and Pharmaceutical agents", Proceedings of the Royal Society of Edinburgh, vol. 99, No. 1-2, 1992, pp. 67-81.
Artman, L.D., et al., "Preferential Inhibitory Effects of Arylamine Spider Toxins on NMDA Receptor-Mediated Increases in Cytosolic Calcium" Society for Neuroscience Abstracts, vol. 17, No. 1-2, 1991, p. 394.
Draguhn, A., et al., Argiotoxin 636 Inhibits NMDA-Activated Ion Channels Expressed in Xenopus Ocytes, Neuroscience Letters, vol. 132, No. 2, 1991, pp. 187-190.
Helke, C.J., et al., Antiextensor Effects of 3, 3-Diphenyl-n-Propylamine in Mouse, European Journal of Pharmacology, vol. 48, No. 3, 1978, pp. 231-235.
Gisvold, S.E., et al., "Drug Therapy in Brain Eschaemia", British Journal of Anesthesia, vol. 57, No. 1 1985, pp. 96-109.
Donevan et al. "GYKI 52466, A 2,3-Benzodiazepine, Is A Highly Selective, Noncompetitive Antagonist Of AMPA/Kainate Receptor Responses" 10 Neuron 51, 1993.
Nakanishi et al. "Bioorganic Studies Of Transmitter Receptors With Philanthotoxin Analogs" Pure & Applied Chemistry vol. 66, #3 (1994).
Williams, "Effects Of Agelenopsis Aperta Toxins On The N-Methyl-D-Aspartate Receptor: Polyamine-Like And High-Affinity Antagonist Actions" 266 The Journal of Pharmacology and Experimental Therapeutics 231, 1993.
Deneris et al. "Pharmacological And Functional Diversity Of Neuronal Nicotinic Acetylcholine Receptors" 12 Trends In Pharmacol. Sci. 34, 1991.
Fisher et al. "Evolving Toward Effective Therapy For Acute Ischemic Stroke" 270 JAMA 360, 1993.
Honore et al. "Quinoxalinediones: Potent Competitive Non-NMDA Glutamate Receptor Antagonists" 24 Science 701, 1988.
Herlitz et al. "Argiotoxin Detects Molecular Differences In AMPA Receptor Channels" 10 Neuron 1131, 1993.
Raditsch et al. "Subunit-Specific Block Of Cloned NMDA Receptors By Argiotoxin.sub.636 " 324 FEBS Lett. 63, 1993.
Reynolds, J.E.F., "Martindale, The Extra Pharmacopoeia",The Pharmaceutical Press, London "Terolidine" 1989, pp. 543-544.
Leszkovszky G., et al., "The Pharmacology of Diphenylalkyl Derivatives" Acta Physiologica Academiae Scientiarum Hungaricae, vol. 29, 1996, pp. 283-298.
Blake, J.C., et al., 2-Methyl-3, 3-Diphenyl-3-Propanolamine (2-MDP) Selectively Antagonises N-Methyl-Aspartate (NMDA), Pharmacology Biochemistry & Behavior, vol. 24, No. 1, 1986, pp. 23-25.
Buschauer, A., et al., Synthesis and Histamine H2 agonistic activity of arpromidine Analogues: Replacement of the Pheniramine-like Moiety by Non-Heterocyclic Groups, Eur. J. Med. Chem, 1992 27:321-330.
Keasling, Hugh H., et al., "Central Nervous System Agents" Journal of Medicinal Chemistry, 1971, vol. 14, No. 11, pp. 1106-1111.
Beckett, A.H., et al., "Configurational Studies in Synthetic Analgesics",J. Chem. Soc., 900(1955).
Camps, Francisco, et al., "New and Efficient One-Pot Preparation of Alkyl Halides From Alcohols", Communications, May 1987, pp. 511-512.
Reist, E.J., et al., "Sodium Azide in Dimethylformamide for the Preparation of Amino-Sugars", Chemistry and Industry, Oct. 13, 1962, pp. 1794-1795.
Moffett, R.B., et al., "Central Nervous System Agents", Journal of Medicinal Chemist
Artman Linda D.
Balandrin Manuel F.
Barmore Robert M.
DelMar Eric G.
Moe Scott T.
NPS Pharmaceuticals Inc.
Raymond Richard L.
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