Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1996-09-20
1999-07-27
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514211, 514213, 514215, 514217, 514220, 540504, 540546, 540547, 540552, 540555, 540557, 540576, 540587, 540593, C07D24338, A61K 3155
Patent
active
059290692
ABSTRACT:
A compound represented by the formula (I) or (II) or a salt thereof wherein R.sup.1 represents hydrogen atom or a C.sub.1-6 alkyl group; R.sup.2 and R.sup.3 independently represent a hydrogen atom or a C.sub.1-6 alkyl group, or R.sup.2 and R.sup.3 may combine together to represent a 5- or 6-membered cycloalkyl group; R.sup.4 represents, for example, a hydrogen atom or a C.sub.1-6 alkyl group; R.sup.5 represents, for example, a hydrogen atom or a C.sub.1-6 alkyl group; R.sup.6 represents a hydrogen atom or a C.sub.1-6 alkyl group; x represents --NR.sup.7 --, --O--, --CHR.sup.7 -- or --S-- in which R.sup.7 represents, for example, a hydrogen atom or a C.sub.1-6 alkyl group; and Y represents a phenylene group or a pyridinediyl group. The compounds are useful as agents for enhancing the activities of retinoid compounds. ##STR1##
REFERENCES:
Chemical & Pharmaceutical Bulletin; vol. 43 (No. 10), pp. 1827-1829 (Oct., 1995).
Journal of Medicinal Chemistry; vol. 37 (No. 10), pp. 1508-1517 (May 13, 1994).
Journal of Organic Chemistry; vol.. 37 (No. 24), pp. 3755-3770 (1972) p. 3759 compound; 38a, 38b, preparation; p. 3568, right column.
Chemical Abstracts; vol. 66, p. 1046 (1967), Abstract No. 10838a, Abstract of Acta Chem. Scand. vol. 20 (No. 6) pp. 1631-1644 (1966).
Institute of Medicinal Molecular Design Inc.
Kessinger Ann
Shah Mukund J.
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