Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1999-04-09
2000-09-19
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540546, 540551, 540547, A61K 3155, C07D28112
Patent
active
061212563
ABSTRACT:
A compound represented by the formula (I) or (II) or a salt thereof wherein R' represents hydrogen atom or a C.sub.1-6 alkyl group; R.sup.2 and R.sup.3 independently represent a hydrogen atom or a C.sub.1-6 alkyl group, or R.sup.2 and R.sup.1 may combine together to represent a 5- or 6-membered cycloalkyl group; R.sup.4 represents, for example, a hydrogen atom or a C.sub.1-6 alkyl group; R.sup.4 represents, for example, a hydrogen atom or a C.sub.1-6 alkyl group; R.sup.6 represents a hydrogen atom or a C.sub.1-6 alkyl group; X represents --NR.sup.7 --, --O--, --CHR.sup.7 -- or --S-- in which R.sup.7 represents, for example, a hydrogen atom or a C.sub.1-6 alkyl group; and Y represents a phenylene group or a pyridinediyl group. The compounds are useful as agents for enhancing the activities of retinoid compounds. ##STR1##
REFERENCES:
patent: 5929069 (1999-07-01), Shudo
Chemical & Pharmaceutical Bulletin; vol. 43 (No. 10), pp. 1827-1829 (Oct., 1995).
Journal of Medicinal Chemistry; vol. 37 (No. 10), pp. 1508-1517 (May 13, 1994).
Journal of Organic Chemistry; vol. 37 (No. 24), pp. 3755-3770 (1972) p. 3759 compound; 38a, 38b, preparation; p. 3568 (3768), right column.
Chemical Abstracts; vol. 66, p. 1046 (1967), Abstract No. 10838a, Abstract of Acta Chem. Scand. vol. 20 (No. 6) p. 1631-44 (1966).
Institute of Medicinal Molecular Design Inc.
Raymond Richard L.
Sripada Pavanaram K.
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