Compounds

Details Compounds Compounds

2011-06-07

2011-06-07

Chang, Celia (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S210210, C514S316000, C546S187000, C546S199000

Reexamination Certificate

active

07956069

ABSTRACT:
Compounds of Formulae I, or pharmaceutically acceptable salts thereof:wherein A1, A2, G1, G2G3, R1, R2, X, Y, Z, m, n and p are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

REFERENCES:
patent: 5665719 (1997-09-01), Bock et al.
patent: 5756497 (1998-05-01), Bell et al.
patent: 5756508 (1998-05-01), Thompson et al.
patent: 6258811 (2001-07-01), Yamauchi et al.
patent: 6812226 (2004-11-01), Baxter et al.
patent: 7273857 (2007-09-01), Kelly et al.
patent: 2007/0259888 (2007-11-01), Cheng et al.
patent: 2009/0076078 (2009-03-01), Cheng et al.
patent: 2009/0221567 (2009-09-01), Cheng et al.
patent: 2009/0221642 (2009-09-01), Jin et al.
patent: 2009/0275574 (2009-11-01), Cheng et al.
patent: 2010/0173935 (2010-07-01), Cheng et al.
patent: 0029707 (1984-02-01), None
patent: 0608858 (1994-01-01), None
patent: 1386920 (2004-02-01), None
patent: 1221443 (2004-09-01), None
patent: 1790637 (2007-05-01), None
patent: 2000323278 (2000-11-01), None
patent: 2002302675 (2002-10-01), None
patent: 9502405 (1995-01-01), None
patent: 9613262 (1996-05-01), None
patent: 9811128 (1998-03-01), None
patent: 9929686 (1999-06-01), None
patent: 9932481 (1999-07-01), None
patent: 0144213 (2001-06-01), None
patent: 0214315 (2002-02-01), None
patent: 02085357 (2002-10-01), None
patent: 02085361 (2002-10-01), None
patent: 03037890 (2003-05-01), None
patent: 03088967 (2003-10-01), None
patent: 03105781 (2003-12-01), None
patent: 2004069828 (2004-08-01), None
patent: 2004089942 (2004-10-01), None
patent: 2004099159 (2004-11-01), None
patent: 2005060711 (2005-07-01), None
patent: 2005060947 (2005-07-01), None
patent: 2005117883 (2005-12-01), None
patent: 2006037052 (2006-04-01), None
patent: 2006038594 (2006-04-01), None
patent: 2006130469 (2006-12-01), None
English abstract for JP 2000-323278.
English abstract for JP 2002-302675.
English abstract for EP 0608858.
English abstract for WO 9811128.
English abstract for WO 2004069828.
English abstract for WO 2006038594.
International Search Report issued for PCT/SE2007/000554 on Sep. 20, 2007.
Cecil Textbook of Medicine, 20th Edition, vol. 2, 1996, pp. 1992-1996.
PubMed Abstract 12621313; J. Cereb Blood Flow Metab., Mar. 2003, 23(3), 381-4.
PubMed Abstract 12910626; J. Soc. Biol., 2003, 197(2), 113-22.
PubMed Abstract 14511112; J. Neurochem, Oct. 2003, 87(2), 344-52.
PubMed Abstract 14561158; Curr. Drug Targets Inflamm Allergy, Sep. 2003, 2(3), 232-41.
Ferrari et al., “Extracellular ATP Triggers IL-1 Release by Activating the Purinergic P2Z Receptor of Human Macrophages,” Journal of Immunology, vol. 159(3), 1997, pp. 1451-1458.
Ferrari et al., “Purinergic Modulation of Interleukin-1 Release from Microglial Cells Stimulated with Bacterial Endotoxin,” J. Exp. Med., vol. 185(3), 1997, pp. 579-582.
Henderson et al., “Inhibition of Interleukin-1-Induced Synovitis and Articular Cartilage Proteoglycan Loss in the Rabbit Knee by Recombinant Human Interleukin-1 Receptor Antagonist,” Cytokine, vol. 3(3), 1991, pp. 246-249.
Kadota et al., “Significance of IL-1 and IL-1 Receptor Antagonist (IL-1Ra) in Bronchoalveolar Lavage Fluid (BALF) in Patients with Diffuse Panbronchiolitis (DPB),” Clin. Exp. Immunol., vol. 103, 1996, pp. 461-466.
Otterness et al., “Possible Role of IL-1 in Arthritis: Effects of Prostaglandins in the Regulation of IL-1 Synthesis and Actions,” Joint Destruction in Arthritis and Osteoarthritis, Agents and Actions Supplements, vol. 39, 1993, pp. 109-120.
Sakito et al., “Interleukin 1, Tumor Necrosis Factor Alpha, and Interleukin 8 in Bronchoalveolar Lavage Fluid of Patients with Diffuse Panbronchiolitis: A Potential Mechanism of Macrolide Therapy,” Respiration, vol. 63, 1996, pp. 42-48.
Yu et al., “Inhibition of IL-1 Release from Human Monocytes and Suppression of Streptococcal Cell Wall and Adjuvant-induced Arthritis in Rats by an Extract of Tripterygium Wilfordii Hook,” General Pharmacology, vol. 25(6), 1994, pp. 1115-1122.

Affiliated with

Also associated with

Rating

Compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2656124