Compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C548S362100

Reexamination Certificate

active

07943651

ABSTRACT:
The present invention provides compounds of formula (I):pharmaceutical compositions comprising the compounds and the use of the compounds for the manufacture of a medicament, particularly for the treatment of inflammation and/or allergic conditions.

REFERENCES:
patent: 4837235 (1989-06-01), Bernstein et al.
patent: 6124334 (2000-09-01), Hutchinson
patent: 6245804 (2001-06-01), Lehmann et al.
patent: 6323199 (2001-11-01), Lehmann et al.
patent: 6344454 (2002-02-01), Lehmann et al.
patent: 6548534 (2003-04-01), Lehmann et al.
patent: 6897224 (2005-05-01), Jaroch et al.
patent: 2005/0131226 (2005-06-01), Rehwinkel et al.
patent: 2005/0171109 (2005-08-01), Rehwinkel et al.
patent: 2005/0209324 (2005-09-01), Rehwinkel et al.
patent: 2005/0222154 (2005-10-01), Rehwinkel et al.
patent: 2005/0234250 (2005-10-01), Lee
patent: 2005/0272823 (2005-12-01), Rehwinkel et al.
patent: 540009 (1995-08-01), None
patent: 98/54159 (1998-06-01), None
patent: 00/32584 (1998-11-01), None
patent: 03/082280 (2003-10-01), None
patent: 03/082787 (2003-10-01), None
patent: 03/082827 (2003-10-01), None
patent: 03/101932 (2003-12-01), None
patent: 03/104195 (2003-12-01), None
patent: 2005/040145 (2004-05-01), None
patent: 2004/063163 (2004-07-01), None
patent: 2005/003098 (2005-01-01), None
patent: 2005/030213 (2005-04-01), None
patent: 2005/034939 (2005-04-01), None
patent: 2005/035518 (2005-04-01), None
patent: 2005/037811 (2005-04-01), None
patent: 2005/095401 (2005-10-01), None
patent: 2006/108699 (2006-10-01), None
Chawla et al., “Challenges in Polymorphism of Pharmaceuticals”, CRIPS vol. 5, No. 1, Jan.-Mar. 2004 (4 Pages).
Newman et al., “Solid-state analysis of the active pharmaceutical ingredient in drug products”, DDT vol. 8, No. 19, Oct. 2003, p. 898-905.
Brittain et al. #2 “Effects of pharmaceutical processing on drug polymorphs and solvates” in Polymorphism in Pharmaceutical Solids, vol. 95, p. 331-361.
Epress-Pharma-Online (http://www.expresspharmaonline.com/20031023/edit02.shtml).
Hacks Chemical Dictionary, Fourth Edition, Julius Grant, 1972, p. 203.
A. Ray et al; Anti-inflammation: direct physical association and functional antagonism between transcription factor NF-KB and the glucocorticoid receptor; Chest; 1995; 107 (3); 139; The American College of Chest Physicians.
H. Schacke et al; Mechanisms Involved in the Side Effects of Glucocorticoids; Pharmacology and Therapeutics; 2002; 96; 23-43; Elsevier.
H. Konig et al; Interference between pathway-specific transcription factors: glucocorticoids antagonize phorbol ester-induced AP-1 activity without altering AP-1 site occupation in vivo; The EMBO Journal; 1992; 11 (6); 2241-6.
P. Barnes et al; Anti-inflammatory actions of steroids: molecular mechanisms; TIPS Reviews; Dec. 1993; 14; 436-441; Elsevier.
A. Cato et al; Molecular Mechanisms of Anti-inflammatory Action of Glucocorticoids; BioEssays; 1998; 18 (5); 371-378.
R. Cumming et al; Use of Inhaled Corticosteroids and the Risk of Cataracts; The New England Journal of Medicine; Jul. 3, 1997; 337/1; 8-14.
C. Wong et al; Inhaled corticosteroid use and bone-mineral density in patients with asthma; The Lancet; Apr. 22, 2000; 355; 1399-1403.
D. B. Allen; Do intranasal corticosteroids affect childhood growth?; Allergy; 2000; 62; 15-18.
R. Pauwels et al; Long-Term Treatment with Inhaled Budesonide in Persons with Mild Chronic Obstructive Pulmonary Disease who Continue Smoking; The New England Journal of Medicine; Jun. 24, 1999; 340/25; 1948-1953.
J. Faul et al; High Dose Inhaled Corticosteroids and Dose Dependent Loss of Diabetic Control; BMJ; Nov. 28, 1998; 317; 1491.
S. Luo et al; Ytterbium Triflate Catalyzed Reactions of Epoxide with Nitrogen Heterocycles Under Solvent-Free Condition; Synthetic Communications; 2003; 33/17; 2989-2994; Marcel Dekker Inc.
R. Andrews et al; Glucocorticoids and insulin resistance: old hormones, new targets; Clinical Science; Apr. 16, 1999; 96; 513-523.
M. Massa et al; Novel Heteroaryl Replacements of Aromatic 3-Tetrafluoroethoxy Substituents in Trifluoro-3-(tertiaryamino)-2-propanols as Potent Inhibitors of Cholesteryl Ester Transfer Protein; Bioorganic & Medicinal Chemistry Letters; 2001; 11; 1625-1628; Pergamon.
T. Lee et al; A Concise Asymmetric Route for the Synthesis of a Novel Class of Glucocorticoid Mimetics Containing a Trifluoromethyl-Substituted Alcohol; Bioorganic & Medicinal Chemistry Letters; 2006; 16; 654-657; Elsevier.
J. Song et al; Practical Stereoselective Synthesis of an alpha-Trifluoromethyl-alpha-alkyl Epoxide via a Diastereoselective Trifluoromethylation Reaction; Journal of Organic Chemistry; 2007; 72; 292-294; American Chemical Society.
Q. Cai et al; Preparation of N-Aryl Compounds by Amino Acid-Promoted Ullmann-Type Coupling Reactions; Synthesis; 2005; 3; 496-499.
A. Klapars et al; A General and Efficient Copper Catalyst for the Amidation of Aryl Halides and the N-Arylation of Nitrogen Heterocycles; Journal of American Chemistry Society; 2001; 123; 7727-7729; American Chemcial Society.
J. Antilla et al; Copper-Diamine-Catalyzed N-Arylation of Pyrroles, Pyrazoles, Indazoles, Imidazoles, and Triazoles; Journal of Organic Chemistry; 2004; 69; 5578-5587; American Chemical Society.
A. Muci et al; Practical Palladium Catalysts for C-N and C-O Bond Formation; Topics of Current Chemistry; 2002; 219; 131-209; American Chemical Society.
M. Van Der Mey et al; Synthesis and Structure-Activity Relationships of cis-Tetrahydrophthalazinone/Pyridazinone Hybrids: A Novel Series of Potent Dual PDE3/PDE4 Inhibitory Agents; Journal of Medicinal Chemistry; 2003; 46; 2008-2016; American Chemical Society.
S. Lulinski et al; Regiospecific Metalation of Oligobromobenzenes; Journal of Organic Chemistry; 2003; 68; 5384-5387; American Chemical Society.
F. Harden et al; Synthesis and Adenosine Receptor Affinity of a Series of Pyrazolo{3,4-d]pyrimidine Analogues of 1-Methylisoguanosine; Journal of Medicinal Chemistry; 1991; 34; 2892-2898; American Chemical Society.
J. Blair et al; Effect of Ring Fluorination on the Pharmacology of Hallucinogenic Tryptamines; Journal of Medicinal Chemistry; 2000; 43; 4701-4710; American Chemical Society.
Express-Pharma-Online (http://www.expresspharmaonline.com/20031023/edit/edit02.shtml).
U.S. Appl. No. 12/226,372, filed Oct. 16, 2008.

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