Compounds

Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals

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Details

436528, 436543, 530333, 530334, 564177, G01N 33543, C07K 104

Patent

active

060048239

ABSTRACT:
The present invention relates to libraries of compounds based upon a N-(4-alkoxyphenyl)-N-acyl-benzylamine, N-(4-alkoxyphenylmethyl)-N-acyl-benzylamine and N-[2-(4-alkoxyphenyl)ethyl]-N-acyl-benzylamine template, to processes for the preparation of such libraries and their use as a screening tool in biological assays for identifying new chemical leads.

REFERENCES:
patent: 5908960 (1999-06-01), Newlander
De Witt, et al., "`Diversomers`: An Approach to Nonpeptide, Nonoligomeric Chemical Diversity", Proc. Natl. Acad. Sci. USA, vol. 90, pp. 6909-6913, (1993).
Jung, et al., "Multiple Peptide Synthesis Methods and Their Applications", Angew. Chem. Int. Ed. Engl., vol. 31, pp. 367-383 (1992).
Pavia, et al. "The Generation of Molecular Diversity", Bioorg. Med. Chem. Lett.,vol. 3, pp. 387-396 (1993).
Lam, et al., "A New Type of Synthetic Peptide Library for Identifying Ligand-Binding Activity", Nature, vol. 354, pp. 82-84, (1991).
Geysen, et al., "Strategies for Epitope Analysis Using Peptide Synthesis", J. Immunol. Meth., vol. 102, pp. 259-274, (1987).
Houghten, et al., "Generation and Use of Synthetic Peptide Combinatorial Libraries for Basic Research and Drug Discovery", Nature, vol. 354, pp. 84-86, (1991).
Lebl, et al., "Multiple Release of Equimolar Amounts of Peptides from a Polymeric Carrier Using Orthogonal Linkage-Cleavage Chemistry", Int. J. Peptide Protein Res., vol. 41, pp. 201-203, (1993).
Ellman, et al., "A General and Expedient Method for the Solid-Phase Synthesis of 1,4-Benaodiazepine Derivatives", Amer. Chem. Soc., vol. 114, pp. 10997-10998, (1992).
Furka, et al., "General Method for Rapid Synthesis of Multicomponent Peptide Mixtures", Int. J. Peptide Protein Res, vol. 37, pp. 476-487, (1991).
Furka, et al., 14th Intl Congress of Biochemsitry, Prague, Jul. 1988.
Wigler, et al., "Complex Synthetic Chemical Libraries Indexed With Molecular Tags", Proc. Nat. Acad. Sci. USA, vol. 90, pp. 10922-10926, (1993).

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