Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-12-13
2011-11-29
Berch, Mark (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S234200, C514S263200, C514S263220, C514S252160, C514S263370, C514S263380, C544S081000, C544S118000, C544S276000
Reexamination Certificate
active
08067411
ABSTRACT:
The present invention provides compounds of formulawherein R1, Y1, X1, Z1, X2, Y2, A, n and R2are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
REFERENCES:
patent: 4179562 (1979-12-01), Ponsford
patent: 4689338 (1987-08-01), Gerster
patent: 4698348 (1987-10-01), Gerster
patent: 4714701 (1987-12-01), Beauchamp
patent: 4912112 (1990-03-01), Seydel et al.
patent: 5736549 (1998-04-01), Beasley et al.
patent: 5994361 (1999-11-01), Penney et al.
patent: 6028076 (2000-02-01), Hirota et al.
patent: 6110923 (2000-08-01), Ely
patent: 6329381 (2001-12-01), Kurimoto et al.
patent: 6376501 (2002-04-01), Isobe et al.
patent: 6448236 (2002-09-01), Monaghan
patent: 6458798 (2002-10-01), Fujita et al.
patent: 6630478 (2003-10-01), Diamond et al.
patent: 6887880 (2005-05-01), Levy et al.
patent: 6951866 (2005-10-01), Fujita et al.
patent: 7157465 (2007-01-01), Isobe et al.
patent: 7642350 (2010-01-01), Pryde
patent: 7691877 (2010-04-01), Jones et al.
patent: 2002/0040032 (2002-04-01), Glasky et al.
patent: 2002/0128264 (2002-09-01), Taylor et al.
patent: 2003/0144283 (2003-07-01), Coleman et al.
patent: 2003/0191086 (2003-10-01), Hanus et al.
patent: 2003/0212092 (2003-11-01), Heppner et al.
patent: 2004/0019048 (2004-01-01), Crooks et al.
patent: 2004/0204438 (2004-10-01), Crooks et al.
patent: 2004/0214192 (2004-10-01), Hashida et al.
patent: 2004/0229897 (2004-11-01), Crooks et al.
patent: 2005/0054590 (2005-03-01), Averett et al.
patent: 2005/0119273 (2005-06-01), Lipford et al.
patent: 2006/0052403 (2006-03-01), Isobe et al.
patent: 2006/0252774 (2006-11-01), Vatner et al.
patent: 2007/0190071 (2007-08-01), Kurimoto et al.
patent: 2007/0225303 (2007-09-01), Ogita et al.
patent: 2007/0249638 (2007-10-01), Giorgio et al.
patent: 2008/0008682 (2008-01-01), Chong et al.
patent: 2008/0269240 (2008-10-01), Hashimoto et al.
patent: 2008/0300244 (2008-12-01), Bonnert et al.
patent: 2009/0047249 (2009-02-01), Graupe et al.
patent: 2009/0082332 (2009-03-01), Abbot et al.
patent: 2009/0099216 (2009-04-01), Millichip et al.
patent: 2009/0105212 (2009-04-01), Isobe et al.
patent: 2009/0118263 (2009-05-01), Hashimoto et al.
patent: 2009/0131458 (2009-05-01), Lazarides et al.
patent: 2009/0143400 (2009-06-01), McInally et al.
patent: 2009/0192153 (2009-07-01), Hashimoto et al.
patent: 2009/0202484 (2009-08-01), Chong et al.
patent: 2009/0209524 (2009-08-01), Bennett et al.
patent: 2009/0281075 (2009-11-01), Roughton et al.
patent: 2009/0324551 (2009-12-01), Carson et al.
patent: 2009/0325877 (2009-12-01), Grunt et al.
patent: 2010/0075995 (2010-03-01), Biggadike et al.
patent: 2010/0087443 (2010-04-01), Bonnert et al.
patent: 2010/0093998 (2010-04-01), Isobe et al.
patent: 2010/0099870 (2010-04-01), Isobe et al.
patent: 2010/0120799 (2010-05-01), Lazarides et al.
patent: 2010/0130491 (2010-05-01), Bonnert et al.
patent: 2010/0240623 (2010-09-01), Cook et al.
patent: 2010/0280001 (2010-11-01), Bonnert et al.
patent: 2010/0298364 (2010-11-01), Bennett et al.
patent: 2011/0028715 (2011-02-01), Isobe et al.
patent: 2011/0054168 (2011-03-01), Kurimoto et al.
patent: 1220148 (1987-04-01), None
patent: 101239980 (2008-08-01), None
patent: 1035123 (2003-08-01), None
patent: 1728793 (2006-12-01), None
patent: 1908480 (2008-04-01), None
patent: 1375162 (1974-11-01), None
patent: 08-165292 (1996-06-01), None
patent: 347422/1997 (1997-11-01), None
patent: 367449/1997 (1997-12-01), None
patent: 367451/1997 (1997-12-01), None
patent: 10-501533 (1998-02-01), None
patent: 11-180981 (1999-07-01), None
patent: 11-180982 (1999-07-01), None
patent: 11-193282 (1999-07-01), None
patent: 2000-159767 (2000-06-01), None
patent: 2004-137157 (2004-05-01), None
patent: 2005-089334 (2005-04-01), None
patent: WO 99/5024 (1999-10-01), None
patent: WO 00/12487 (2000-03-01), None
patent: WO 00/76519 (2000-12-01), None
patent: WO 03/011864 (2003-02-01), None
patent: WO 2004/011481 (2004-02-01), None
patent: WO 2004/075865 (2004-09-01), None
patent: WO 2004/087049 (2004-10-01), None
patent: WO 2005/092892 (2005-10-01), None
patent: WO 2005/092893 (2005-10-01), None
patent: WO 2006/029115 (2006-03-01), None
patent: WO 2006/091394 (2006-08-01), None
patent: WO 2007/031726 (2007-03-01), None
patent: WO 2007/034173 (2007-03-01), None
patent: WO 2007/034817 (2007-03-01), None
patent: WO 2007/034881 (2007-03-01), None
patent: WO 2007/034882 (2007-03-01), None
patent: WO 2007/034916 (2007-03-01), None
patent: WO 2007/034917 (2007-03-01), None
patent: WO 2007/093901 (2007-08-01), None
patent: WO 2008004948 (2008-01-01), None
patent: WO 2008/114006 (2008-09-01), None
patent: WO 2008/114008 (2008-09-01), None
patent: WO 2008/114817 (2008-09-01), None
patent: WO 2008/114819 (2008-09-01), None
patent: WO 2008/135791 (2008-11-01), None
patent: WO 2009067081 (2009-05-01), None
patent: WO 2009/078798 (2009-06-01), None
patent: WO 2009091031 (2009-07-01), None
patent: WO 2009091032 (2009-07-01), None
patent: WO 2010018131 (2010-02-01), None
patent: WO 2010018134 (2010-02-01), None
patent: WO 2010/033074 (2010-03-01), None
patent: WO 2010/133882 (2010-11-01), None
Chavarot, “Synthesis of an adenine-pyridinaldoxime-acridine conjugate for recognition of abasic site lesions in DNA,” Tetrahedron, 1997, 53(40), pp. 13749-13756.
Dvorakova, “Synthesis of 2′-aminomethyl derivatives of N-(2-(phosphonomethoxy)ethyl) nucleotide analogues as potential antiviral agents,” J. Med. Chem., 1996, 39(17), pp. 3263-3268.
Hirota et al., “Discovery of 8-hydroxyadenines as a novel type of interferon inducer,” J. Med. Chem., 2002, 45 (25), pp. 5419-5422.
Holy et al., “Studies on S-adenosyl-L-homocysteine hydrolase. XVI. 9-(Aminoalkyl)-8-hydroxyadenines: preparation mechanism of formation, and use in affinity chromatography of S-adenosyl-L-homocysteine hydrolase,” Collection of Czechoslovak Chemical Communications (1986), 51(2), pp. 459-477.
Isobe et al., “Synthesis and structure-activity relationships of 2-substituted-8-hydroxyadenine derivatives as orally available interferon inducers without emetic side effects,” Bioorganic & Medicinal Chemistry, 2003, 11(17), pp. 3641-3647.
Isobe, Y et al., “Synthesis and biological evaluation of novel 9-substituted-8-hydroxyadenine derivatives as potent interferon inducers,” J. Med. Chem., 2006, 49 (6), pp. 2088-2095.
Itahara, “Control of liquid-crystalline properties by base pairing of adenine and thymine,” ChemPhysChem, 2002, 3(4), pp. 378-379.
Kurimoto et al., “Prodrugs of 9-benzyl-8-hydroxy-2-(2-hydroxyethylthio)adenine: potent interferon inducing agents in monkeys,” Chemical & Pharmaceutical Bulletin, 2004, 52(4), pp. 466-469.
Kurimoto et al., “Synthesis and biological evaluation of 8-oxoadenine derivatives as Toll-like Receptor 7 agonists introducing the antedrug concept,” J. Med. Chem., 2010, 53, pp. 2964-2972.
Kurimoto et al., “Synthesis and evaluation of 2-substituted 8-hydroxyadenines as potent interferon inducers with improved oral bioavailabilities,” Bioorganic & Medicinal Chemistry, 2004, 12(5), pp. 1091-1099.
Kurimoto et al., “Synthesis and structure-activity relationships of 2-amino-8-hydroxyadenines as orally active interferon inducing agents,” Bioorganic & Medicinal Chemistry, 2003, 11(24), pp. 5501-5508.
Priority Document of WO 2009005687, (2007).
Spassova et al., “Synthesis ofN-(3-Azido-2-hydroxypropyl),N-(3-Phthalimido-2-hydroxypropyl) andN-(3-Amino-2-hydroxypropyl) Derivatives of Heterocyclic Bases,” Collection of Czechoslovak chemical Communications (1994), 59(5), 1153-1174.
“Asthma” (MDAdvice.com) retrieved on Jun. 24, 2010 from the internet (URL: http://www.mdadvice.com/topics/asthma/info/1.htm).
“Chronic obstructive pulmonary disease”(AllRefer.com Health) retrieved on Jun. 24, 2010 from the internet (URL: http://health.allrefer.com/health/chronic-obstructive-pulmonary-disease-prevention.html).
“Respira
Bonnert Roger Victor
McInally Thomas
Mochel Tobias
Thom Stephen
AstraZeneca AB
Berch Mark
Dainippon Sumitomo Pharma Co. ,Ltd.
Morgan & Lewis & Bockius, LLP
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