Compounds

Details Compounds Compounds

2003-08-08

2008-08-12

Davis, Zinna N (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S190000

Reexamination Certificate

active

07410984

ABSTRACT:
The present invention relates to novel pyridone derivatives capable of inhibiting α4integrin mediated cell adhesion, processes for their preparation, compositions comprising them and their use in the treatment of diseases capable of being modulated by the inhibition of cell adhesion.

REFERENCES:
patent: WO-00/37444 (2000-06-01), None
Chang L L et al. “The Discovery of Small Molecule Carbamates as Potent Dual Alpha4Beta1/Alpha4Beta7 Integrin Anatagonists” Bioorganic & Medicinal Chemistry Letters, Oxford, GB, vol. 12, No. 2, 2002, pp. 159-163.
Lobb et al., Expert Opinion on Investigational Drugs, vol. 8, pp. 935-945, (1999).
Sircar et al., Bioorganic & Medical Chemistry, vol. 10, pp. 2051-2066, (2002).
Butcher, E. C., Cell, vol. 67, pp. 1033-1036, (1991).
Harlan, J. M., Blood, vol. 65, No. 3, pp. 513-525, (1985).
Hemler, M. E., Annu. Rev. Immunol., vol. 8, pp. 365-400, (1990).
Osborn, L., Cell, vol. 62, pp. 3-6, (1990).
Springer, T. A., Nature, vol. 346, pp. 425-434, (1990).
Springer, T. A., Cell, vol. 76, pp. 301-314, (1994).
Wayner, E. A., J. of Cell Biology, vol. 105, pp. 1873-1884, (1987).
Bornstein, P., Ann. Rev. Biochem., vol. 49, pp. 957-1003, (1980).
Miller, E. J., Chemistry of the collagens and their distribution, in “Extracellular Matrix Biochemistry”, K.A. Piez and H.A. Reddi, editors, Elsevier, Amsterdam, pp. 41-78, (1983).
Hynes, R. O., Cell, vol. 48, pp. 549-554, (1987).
Shimizu et al., Immun. Reviews, No. 114, pp. 109-143, (1990).
Hemler, M. E., J. of Bio. Chem., vol. 262, No. 24, pp. 11478-11485, (1987).
Bochner, B. S., J. Exp. Med., vol. 173, pp. 1553-1556, (1991).
Ibbotson et al., Nature Medicine, vol. 7, No. 4, pp. 465-470, (2001).
Elices et al., Cell, vol. 60, pp. 577-584, (1990).
Wayner et al., J. of Cell Biol., vol. 109, pp. 1321-1330, (1989).
Bayless et al., J. of Cell Science, vol. 111, pp. 1165-1174, (1998).
Cheng et al., Biochem. Pharmacology, vol. 22, pp. 3099-3108, (1973).

Affiliated with

Also associated with

Rating

Compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3999659