Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-06-20
2006-06-20
Habte, Kahsay (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S235000
Reexamination Certificate
active
07064126
ABSTRACT:
The invention relates to thienopyridazinones of formula (I): wherein: R1is C1-6alkyl, C2-6alkenyl or C3-6cycloalkyl which is optionally substituted by C1-6alkyl, each of the above being optionally substituted by one or more halogen atoms; R2is C1-6alkyl; R3is a group CO—G or SO2—G where G is a 5- or 6-membered ring containing a nitrogen atom and a second heteroatom selected from oxygen and sulphur adjacent to the nitrogen, and optionally substituted by up to 3 groups selected from hydroxyl and C1-4alkyl; Q is CR5R6where R5and R6are as defined in the specification; and R4is a 5- to 10-membered mono- or bi-cyclic aromatic ring system, containing 0 to 4 heteroatoms independently selected from nitrogen, oxygen and sulphur, the ring system being optionally substituted as described in the specification, and pharmaceutically acceptable salts and solvates thereof. Processes for their preparation, pharmaceutical compositions containing them and their use in therapy, in particular in the modulation of autoimmune disease are also described.
REFERENCES:
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Yamaguchi et al., “Novel Antiasthmatic Agents with Dual Activities of Thromboxane A2Synthetase Inhibition and Bronchodilation. V.1)Thienopyridazinone Derivatives”,Chem. Pharm. Bull.43(2):236-240 (1995).
Cooper Martin Edward
Guile Simon David
Ingall Anthony Howard
Rasul Rukhsana Tasneem
AstraZeneca AB
Habte Kahsay
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