Compounds

Details Compounds Compounds

1989-10-10

1992-11-24

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546112, 546133, 548181, 548234, 548235, 548236, 548241, A61K 31435, C07D47108

Patent

active

051663570

ABSTRACT:
A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## in which one of X and Y represents hydrogen and the other represents Z, where Z is a group ##STR2## in which Q represents a 3-membered divalent residue completing a 5-membered aromatic ring and comprises one heteroatom selected from oxygen, nitrogen and sulphur or two heteroatoms selected from sulphur and nitrogen, any amino nitrogen being optionally substituted by a C.sub.1-2 alkyl, and at least one ring carbon atom being substituted by a group R.sub.1 ; or a group ##STR3## in which A.sub.1, A.sub.2 and A.sub.3 complete a 5-membered aromatic ring and A.sub.1 is oxygen or sulphur, A.sub.2 is CR.sub.2 and A.sub.3 is nitrogen or CH, or A.sub.2 is oxygen or sulphur, A.sub.1 is CH and A.sub.3 is CR.sub.2 ; and R.sub.1 and R.sub.2 are selected from, halogen, CN, OR.sub.4, SR.sub.4, N(R.sub.4).sub.2, NHCOR.sub.4, NHCOOCH.sub.3, NHCOOC.sub.2 H.sub.5, NHOR.sub.4 NHNH.sub.2, NO.sub.2, COR.sub.4, COR.sub.5, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl or C.sub.1-2 alkyl substituted with OR.sub.4, N(R.sub.4).sub.2, SR.sub.4, CO.sub.2 R.sub.4, CON(R.sub.4).sub.2 or one, two or three halogen atoms, in which each R.sub.4 is independently hydrogen or C.sub.1-2 alkyl and R.sub.5 is OR.sub.4, NH.sub.2 or NHR.sub.4 ; r represents an integer of 2 or 3, s represents an integer of 1 or 2 and t represents 0 or 1, with the proviso that when Y is hydrogen s is 1.

REFERENCES:
patent: 4968691 (1990-11-01), Orlek
patent: 4971975 (1990-11-01), Hadleg
Chem. Abs., vol. 80, No. 15, Apr. 15, 1974, E. E. Mikhlina et al.
"Synthesis . . . 2-[quinuclidinyl]-substituted imidazolines . . . " Journal of Organic Chemistry, vol. 34, No. 1, 3674-6 (1969).
D. O. Spry, "Azabicyclic Alcohols. VI. Stereospecific Syn . . . ".

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