Compounds

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...

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514 2, 435 691, 4352523, 4353201, 536 237, A61K 3816, A61K 3909, C07K 14315, C12N 1531, C12N 1574

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active

060013621

ABSTRACT:
The invention provides Response regulator polypeptides and DNA (RNA) encoding Response regulator polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Response regulator polypeptides to screen for antibacterial compounds.

REFERENCES:
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patent: 5773250 (1998-06-01), Wallis
patent: 5824538 (1998-10-01), Branstrom et al.
patent: 5882889 (1999-03-01), Wallis
Roychoudhury, S., et al., Proceedings of the National Academy of Sciences, U.S.A., vol. 90, "Inhibitors of two-component signal transduction systems: Inhibition of alginate gene activation in Pseudomonas aeruginosa", pp. 965-969, 1993.
Ogasawara, N., et. al., Systematic Sequencing of the 180 Kilobase Region of the Bacillus subtilis Chromosome Containing the Replication Origin. (1994) DNA Research 1:1-14.
Volz, K., Structural Conservation in the CheY Superfamily. (1993) Biochemistry 32(44):11741-11753.
Volkman, B.F., et. al., Three Dimensional Solution Structure of the N-Terminal Receiver Domain of NTRC. (1995) Biochemistry 34:1413-1424.
Matsumura, P., et. al., Overexpression and Sequencing of the Escherichia coli che Y Gene and Biochemical Activities of the CheY Protein. (1984) J. Bacteriology 160(1):36-41.
Feher, V .A., et. al., .sup.1 H, .sup.15 N, and .sup.13 C backbone chemical shift assignments, secondary structure, and magnesium-binding characteristics of the Bacillus subtilis response regulator, Spo0F, determined by heteronuclear high-resolution NMR. (1995) Protein Science 4:1801-1814.
P37478 located in the Swissprot Database on the World Wide Web. Database address is Amos Bairoch, Medical Biochemistry Department Centre, Medical Universitaire 1, Rue Michele Servet 1211 Geneva VI, Switzerland, (1994).

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