Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Reexamination Certificate
2008-04-29
2008-04-29
Davis, Brian (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
C564S426000, C564S428000, C564S429000, C564S440000, C564S443000, C568S030000, C568S586000, C514S648000, C514S656000, C514S657000
Reexamination Certificate
active
07365231
ABSTRACT:
The present invention provides the diaminophenyladamantane derivatives with antitumor activities and the preparation method therefore. The method includes a step of reacting an aromatic diol with at least one 5-halo-2-nitrophenol in the presence of at least one inorganic base in an organic solvent with a relatively high boiling point.
REFERENCES:
Database CAPLUS on STN, Acc. No. 1994:164950, Winzeler et al., Polymer Preprints (ACS Division of Polymer Chemistry) (1993), 34(1), p. 425-6 (abstract).
Database CAPLUS on STN, Acc. No. 2004:738900, Fujimoto et al., JP 2004250438 (Sep. 9, 2004) (abstact).
Sherr, Charles J. , “Cancer Cell Cycles”, Science, vol. 274: 1672-7 (Dec. 1996).
Aigami, Koji, Y. Inamoto, N. Takaishi and K. Hattori, “Biologically Active Polycycloalkanes. 1. Antiviral Adamantane Derivatives”, J. Med. Chem., vol. 18: 713-21 (1975).
Tverdislov, V. A., et al., “Interaction of the Antivirus Agents Remantadine and Amantadine with Lipid Membranes and the Influence on the Curvature of Human Red Cells”, Gen. Physiol. Biophys. 5, 61-75 (1986).
Komhuber, J., J. Bormann, M. Hubers, K. Rusche and P. Riederer, “Effects of the 1-amino-adamantanes at the MK-801-binding site of the NMDA-receptor-gated ion channel: a human postmortem brain study”, European Journal of Pharmacology—Molecular Pharmacology Section, 206: 297-300 (1991).
Donath, Edwin, et al. “The Influence of the Antiviral Drugs Amantadine and Rimantadine on Erythrocyte and Platelet Membranes and its Comparison with that of Tetracaine”, Biochemical Pharmacology 36:481-7 (1987).
Wang, J-J, Y-T Chern, Y-F Chang, T-Y Liu and C-W Chi, “Dimethyladamantylmaleimide-induced in vitro and in vivo growth inhibition of human colon cancer Colo205 cells”, Anti-Cancer Drugs 13: 533-43 (2002).
Wang, J-J, Y-T Chern, Y-F Chang, T-Y Liu and C-W Chi, “In vitro and in vivo growth inhibition of cancer cells by adamantylmaleimide derivatives”, Anti-Cancer Drug Design, 13: 779-796 (1998).
Wang, J-J, K-T Huang and Y-T Chern, “Induction Of Growth Inhibition And G1 Arrest in Human Cancer Cell Lines By Relatively Low-Toxic Diamantane Derivatives”, Anti-Cancer Drugs 15:277-286 (2004).
Wang, J-J, Y-F Chang, Y-T Chern, and C-W Chi, “Study of in vitro and in vivo effects of 1,6Bis[4-(4-amino-3-hydroxyphenoxyl)phenyl]diamantane (DPD), a novel cytostatic and differentiation inducing agent, on human colon cancer cells”, British Journal of Cancer, 89(10):1995-2003 (2003).
Attia, Mohammed A. M. and David W. Weiss, “Immunology of Spontaneous Mammary Carcinomas in Mice V. Acquired Tumor Resistance and Enhancement in Strain A Mice Infected with Mammary Tumor Virus”, Cancer Research 26, Part 1: 1787-1800 (1966).
Wang, J-J, Y-C Chen, C-W Chi, K-T Huang and Y-T Chern, “In vitro and In vivo Growth Inhibition and G1 Arrest in Human Cancer Cells By Diaminophenyladamantane Derivatives”, Anti-Cancer Drugs, 15: 697-705.
Davis Brian
National Taiwan University of Science & Technology
Volpe & Koenig PC
LandOfFree
Compound with antitumor activity and preparation method... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compound with antitumor activity and preparation method..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compound with antitumor activity and preparation method... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2778679