Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing
Patent
1989-02-03
1990-06-26
Gray, Bruce
Organic compounds -- part of the class 532-570 series
Organic compounds
Oxygen containing
C07C 4302
Patent
active
049373900
ABSTRACT:
The present invention relates to the use of the compound D-3-deoxy-3-fluoro-4-O-methyl-myo-inositol for the synthesis of D-3-deoxy-3-fluoro-myo-inositol.
REFERENCES:
patent: 1758616 (1930-05-01), McGarack et al.
patent: 3887590 (1975-06-01), Cier et al.
patent: 4474806 (1984-10-01), Beattie et al.
patent: 4515722 (1985-05-01), Yang et al.
J. Gigg et al., The Allyl Group for Protection and Carbohydrate Chemistry. Part 18, Allyl and Benzyl Ethers of Myo-Inositol. Intermediates for the Synthesis of Myo-Inositol Trisphosphates, Journal Chemical Society Perkin Trans., 423-429 (1987).
S. S. Yang et al., DAST-Induced Epimerization of a 2-(acetoxymethyl) myoinositol, Journal Organic Chemistry, 46, 1718-1720 (1981).
W. J. Middleton, New Flurinating Reagents. Dialkylaminosulphur Fluorides, Journal Organic Chemistry, 40, 574-578 (1975).
S. S. Yang et al., Synthesis of 2-ax-Fluoro-2-eq-Hydroxymethyl-2-deoxymyoinositol, Synthetic Communications 16, 131-138 (1986).
C. Jiang et al., Synthesis of Deoxy and Deoxy-halogeno Analogues of myo-Inositol, Journal Carbohydrate Chemistry, 6, 319 355 (1987).
S. Ozaki, Synthesis of D-Myo-Inositol 1,3,4,5-Tetrakisphosphate, Tetrahedron Letters, 28, 4691-4694 (1987).
S. S. Yang et al., Synthesis of Fluorodeoxy-scylloinositol and Phosphatidylfluorodeoxyscylloinositol, Tetrahedron Letters, 23, 5517-5520 (1982).
M. Hamblin et al., Bisphosphorylation of a vic-Diol Using a Phosphite Approach: Synthesis of myo-Inositol 4,5-Bisphosphate, Journal Chem. Society, Chem. Communications, 626-627 (1987).
J. P. Vacca et al., Total Synthesis of D- and L-myo-inositol 1,4,5-trisphosphate, Journal American Chemical Society, 109, 3478-3479 (1987).
S. P. Ozaki et al., Total Synthesis of Optically Active Myo-Inositol 1,4,5-Tris(phosphate), Tetrahedron Letters, 27, 3157, 3160 (1986).
D. Billington et al., Synthesis of myo-Inositol 1,3,4,5-tetraphosphate and myo-Inositol 1,3,-Bisphosphate, Journal Chemical Society, Chem. Communications, 1011-1013 (1987).
Y. Watanabe et al., Stepwise Phosphorylation of Vicinal Diol and Sterically Hindered Alcohol Directed Toward D-Myo Inositol 2,4,5 Triphosphate, Tetrahedron Letters, 28, 2607-2610 (1987).
C. B. Reese et al., Synthesis of D-myo-Inositol 1,4,5-Trisphosphate, Tetrahedron Letters, 28, 2309-2312 (1987)(.
J. D. Moyer et al., Substrate Properties of Analogs of myo-Inositol, Molecular Pharmacology, 33, 683-689 (1988).
M. A. Polokoff et al., Metabolism of Synthetic Inositol Triphosphate Analogs, The Journal of Biological Chemistry, 263, 11922-11927 (1988).
T. A. Suami et al., Inositol Derivatives, 7, Azidolysis of Disulfonate of myo-Inositol and 1,2-0-Cyclohexylidine Derivative, Bulletin of the Chemical Society of Japan, 47, 1731-1736 (1974).
N. Kurihara et al., Chemistry of Benzene glycols, Part XVII, A New Synthesis of Streptamine, Agra. Biol. Chem., 31, 1166-1170 (1967).
S. J. deSolms, The Total Synthesis of (.+-.)-myo-inositol-1,3,4-Trisphosphate, (.+-.)-Myo-Inositol-1,3,4,5 Tetrikisphosphate, Tetrahedron Letters, 28, 4503-4506 (1987).
A. P. Kozikowski et al., A Synthesis of (-)-1L-1 14 Deoxy-1-fluoro-myo-inositol; a Compound of Potential Use in Sorting Out the Phosphatidylinositol Response, J. Chem. Soc., Chem. Commun., 1301-1303 (1988).
M. F. Boehm et al., Fluorinated Analogs and Tritiated Enantiomers of Inositol (1,3,4)-Trisphosphate, Tetrahedron Letters, vol. 29, 41, 5217-5220 (1988).
Gray Bruce
University of Pittsburgh
LandOfFree
Compound useful for the production of 3-deoxy-3-fluoro-myo-inosi does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compound useful for the production of 3-deoxy-3-fluoro-myo-inosi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compound useful for the production of 3-deoxy-3-fluoro-myo-inosi will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1126808