Compound UCA1064-B

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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546 77, 435127, C07D21512

Patent

active

052369293

ABSTRACT:
Disclosed is UCA1064-B, a compound represented by formula (I): ##STR1## and having an antibacterial, antifungal and anti-tumor activity. UCA1064-B is produced by culturing a microorganism belonging to the genus Wallemia.

REFERENCES:
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patent: 3972884 (1976-08-01), Jones
patent: 4008238 (1977-02-01), Jones
patent: 4039547 (1977-08-01), Chamberlin
Folkman et al., Science, vol. 221, pp. 719-725 (1983).
Mori et al., Heterocycles, vol. 24, pp. 1257-1260 (1986).
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"Influence of Solute, pH, and Incubation Temperature on Recovery of Heat-Stressed Wallemia-sebi Conidia", vol. 113, No. 19, Nov. 5, 1990, Columbus, Ohio, Abstract No. 170561, p. 582.
"Study on a Toxic Metabolite from the Mold Wallemia", vol. 112, No. 17 Apr. 23, 1990, Columbus, Ohio, Abstract No. 153394, p. 243.
"Affects of Water Activity and Culture Age on the Glycerol Accumulation Patterns of Five Fungi", vol. 104, No. 19, May 12, 1986; Columbus, Ohio, Abstract No. 165010, p. 351.
"Natural-Abundance Carbon-13 Nuclear Magnetic Resonance Studies on the Internal Solutes of Xerophilic Fungi", vol. 99, No. 23, Dec. 5, 1983, Columbus, Ohio, Abstract No. 191221, p. 433.
Journal of the Chemical Society Perkin Transaction I, No. 13, 1973, Letchworth, G.B., pp. 1416-1424, "Natural and Synthetic Pyrrol-2-ylpolyenes".
Journal of Antibiotics, vol. 27, No. 12, Dec. 1974, Tokyo, JP, pp. 992-993; J. W. Chamberlin et al., "Structure of Antibiotic", A-25822-B, A Novel Nitrogen-Containing C28-Sterol with Anti-Fungal Properties.

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