Compound produced by a strain of microtetraspora having antibact

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

548517, A61K 3140, C07D40512

Patent

active

052665887

ABSTRACT:
Disclosed is a novel compound, designated BU-4514N, which is produced by cultivation of a novel strain of Microtetraspora, designated species T689-92. The novel compound possesses antibacterial and neuritogenic properties.

REFERENCES:
patent: 5075305 (1991-12-01), Hobbs et al.
patent: 5082670 (1992-01-01), Gage et al.
patent: 5098902 (1992-03-01), Hobbs et al.
E. B. Shirling and D. Gottlieb, "Methods for Characterization of Streptomyces Species" Intern. J. Syst. Bact. 16, (1966) 313-340.
S. A. Waksman, In "The Actinomycetes. vol. II. Classification, Identification and Description of Genera and Species" The Williams & Wilkins Co., Baltimore, 1961, 318-334.
T. Arai, In "Culture Media for Acetinomycete" The Society for Acetinomycetes Japan, 1975.
Gauze, et al. "Problems in the Classification of Antagonistic Actinomycetes" State Publishing House for Medical Literature, Medzig, Moscow, 1957.
Lechevalier, et al. "A Critical Evaluation of the General of Aerobic Actinomycetes" In The Actinomycetales (H. Prauser, ed.) pp. 393-405, Jena, Gustav Fisher Verlag, 1970.
J. L. Staneck & G. D. Roberts, "Simplified Approach to Identification of Aerobic Actinomycetes by Thin-Layer Chromatography" Applied Microbiology, 28, 1974, 226-231.
Lechevalier, et al., "Chemotaxonomy of Aerobic Actinomycetes: Phospholipid Composition,", Biochem. Syst. Ecol. 5, 1977, pp. 249-260.
Minnikin, et al., "Differentiation of Mycobacterium, Nocardia and Related Taxa by Thin-Layer Chromatographic Analysis of Whole-Organism Methanolysates," J. Gen Microbiol. 88, 1975 pp. 200-204.
Collins, et al., "A note on the Separation of Natural Mixtures of Bacterial Menaquinones Using Reverse-phase Thin-layer Chromatography" J. Appl. Bacteriol. 48, 1980, pp. 277-282.
Suzuki, et al., "Taxonomic Significance of Cellular Fatty Acid Composition in Some Coryneform Bacteria" Int. J. Systm. Bacteriol. 33 (1983) 188-200.
Kroppenstedt, et al. "Taxonomic Erevision of the Actinomycete Genera Actinomadurae and Microtetraspora" System Appl. Microbiol. 13 (1990) 148-160.
Hayakawa, et al. "Lydicamycin, A New Antibiotic of a Novel Skeletal Type. II. Physico-chemical Properties and Structure Elucidation" J. Antibiotics 44 (1991) 288-292.
H. Thoenen and Y. A. Barde, "Physiology of Nerve Growth Factor" Physiol. Rev. 60 (1980) 1284-1335.
Whittemore, et al. "The Expression Localization and Functional Significance of beta-Nerve Growth Factor in the Central Nervous System" Brain Res. Rev. 12 (1987) 439-464.
Goelet, et al., "The Long and the Short of Long-term Memory--A Molecular Framework" Nature, 322 (1986) 419-422.
Schwartz, et al., "Molecular Mechanisms for Memory: Second-Messenger Induced Modifications of Protein Kinases in Nerve Cells" Ann. Rev. Neurosci., 10 (1987) 459-476.
Eppler, et al., "Structural Studies on a Family of cAMP-binding Proteins in the Nervous System of Aplysia" J. Cell Biol., 102 (1986) 320-321.
Scholz, et al., "Long-Term Sensitization in Aplysia: Biophysical Correlates in Tail Sensory Neurons" Science, 235 (1987) 685-687.
Weiss, et al., "Modulation of Buccal Muscle Contractility by Serotonergic Metacerebral Cells in Aplysia" J. Neurophysiol. 42 (1979) 791-803.
Fischer, et al., "Amelioration of Cholinergic Neuron Atrophy and Spatial Memory Impairment in Aged Rats by Nerve Growth Factor" Nature, 329, (1987) 65-68.
Furukawa, et al., "Catecholamines Induced an Increase in Nerve Growth Factor Content in the Medium of Mouse L-M Cells" J. Biol. Chem., 261 (1986) 6039-6047.
Furukawa, et al., "Regulation of Nerve Growth Factor Synthesis/Secretion by Catecholamine in Cultured Mouse Astroglial Cells" Biochem. Biophys. Res. Commun., 147, (1987) 1048-1054.
Tsuji, et al., "GQ1B, A Bioactive Bioactive Ganglioside that Exhibits Novel Nerve Growth Factor (NGF)-Like Activities in the Two Neuroblastoma Cell Lines" J. Biochem. 94 (1983) 303-306.
Cuello, et al. "Gangliosides Potentiate in vivo and in vitro Effects of Nerve Growth Factor on Central Cholinergic Neurons" Proc. Natl. Acad. Sci., 86 (1989) 2056-2060.
Wu, et al., "Stimulation of Neurite Outgrowth in Neuroblastoma Cells by Neuraminidase: Putative Role of GM1 Ganglioside in Differentiation" J. Neurochem. 56 (1991) 95-104.
Tsuji, et al., "Synthetic sialyl Compounds as well as Natural Gangliosides Induce Neuritogenesis in a Mouse Neuroblastoma Cell Line (Neuroza)" J. Neurochem. 50 (1988) 414-423.
Himi, et al. "Effect of Ginzeng Saponins on the Survival of Cerebral Cortex Neurons in Cell Cultures" Chem. Pharm. Bull. 37 (1989) 481-484.
Wion, et al, "1,25-Dihydroxyvitamin D.sub.3 Is a Potent Inducer of Nerve Growth Factor Synthesis" J. Neurosci. Res., 28 (1991) 110-114.
Huffaker, et al., "Adenosine Inhibits Cell Division and Promotes Neurite Extension in PC12 Cells" J. Cell Physiol., 120 (1984) 188-196.
Guroff, et al., "The Action of Adenosine Analogs on PC12 Cells" J. Neurochem., 37 (1981) 1431-1439.
Morioka, et al., "Staurosporine-induced Differentiation in a Human Neuroblastoma Cell Line, NB-1" Agric. Biol. Chem., 49 (1985) 1959-1963.
Omura, et al. "Lactacystin, A Novel Microbial Metabolite, Induces Neuritogenesis of Neuroblastoma Cells" J. Antibiotics 44 (1991) 113-116.
Wion, et al. "Serum and Thyroid Hormones T3 and T4 Regulate Nerve Growth Factor MRNA Levels in Mouse L Cells" FEBS Lett., 189 (1985) 37-41.
Wion, et al., "Retinoic Acid Increases the Expression of NGF Gene in Mouse L Cells" Biochem. Biophys. Res. Commun. 149 (1987) 510-514.
Wion, et al., "Phorbol 12-Myristate 13-Acetate (PMA) Increases the Expression of the Nerve Growth Factor (NGF) Gene in Mouse L-929 Fibroblasts" FEBS Lett., 262 (1990) 42-44.
K. N. Prasad and S. Kumar "Role of Cyclic AMP in Differentiation of Human Neuroblastoma Cells in Culture" Cancer, 36 (1975) 1338-1343.
Greene et al. "Establishment of a Noradrenergic Clonal Line of Rat Adrenal Pheochromocytoma Cells Which Respond to Nerve Growth Factor" Proc. Natl. Acad. Sci. USA 73 (1976) 2424-2428.
Hama, et al., "Protein Kinase C as a Component of a Nerve Growth Factor-Sensitive phosphorylation System in PC12 Cells" Proc. Natl. Acad. Sci. USA, 83 (1986) 2353-2357.
Olson, et al. "Intraputaminal Infusion of Nerve Growth Factor to Support Adrenal Medullary Autografts in Parkinson's Disease" Arch. Nuerol. 48 (Apr. 1991) 373-381.
Tischler and Greene, Nature, 258 (1975) 341-342.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Compound produced by a strain of microtetraspora having antibact does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compound produced by a strain of microtetraspora having antibact, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compound produced by a strain of microtetraspora having antibact will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2096683

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.