Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Polymers from only ethylenic monomers or processes of...
Reexamination Certificate
2001-08-20
2004-03-09
Pezzuto, Helen L. (Department: 1713)
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Polymers from only ethylenic monomers or processes of...
C526S288000, C526S304000, C526S307000, C526S312000, C526S318300
Reexamination Certificate
active
06703468
ABSTRACT:
TECHNICAL FIELD
The present invention relates to a polymer useful as a raw material for cosmetics and the like, a method for producing the polymer, and a composition containing the polymer. The present invention also relates to a method for producing compounds useful as monomers for synthesis of the polymer compound. The present invention further relates to a fluorescence-labeled polymer, and a method for protecting or improving skin.
BACKGROUND ART
Skin conditions greatly influence people's appearance, and skin also plays an important role, i.e., it protects living bodies by its barrier function from pathogenic microorganisms, external physical stimuli such as heat, dryness, moisture and friction, toxic substances and the like. Therefore, it must be said that it is a big object to protect or improve skin from the viewpoints of maintenance of beauty, health, living bodies and the like.
As currently used approaches for treating damaged skin or injured skin, there can be mentioned winding a bandage on such damaged skin to protect it from external stimuli, pathogenic organisms and the like, applying compositions for topical to skin containing anti-inflammatory or anti-bacterial ingredients, or spraying such compositions as aerosol and the like. These approaches are all based on separation of the skin from factors harmful for skin, or prevention of penetration of such factors, and they do not directly act on the skin. Thus, recovery of skin functions itself is left to depend on physiological functions. That is, there have currently been no means for positively recovering the skin structure itself.
Moreover, there frequently exist on skin surface damages degrading proper functions or appearance of skin, even though they are not so serious as those generally referred to as damaged skin, injured skin or rough skin. For such mild skin damages, there have also been only the same procedures as those for damaged skin and injured skin mentioned above.
By the way, since molecular weight of polymers is easily controlled, and polymers of various properties can be prepared by selecting monomers, they are utilized in various fields. Furthermore, in recent years, there have been developed polymers contributing improvements of people's appearance and health in the fields of cosmetics, pharmaceuticals and the like, including those for coiffure agents, moisturizers, biomaterial polymers and the like. However, there have never been known polymers having groups exhibiting affinity for skin on their structures, and thereby exhibiting beneficial effects on skin functions, for example, excellent moisturizing property, skin damage healing property and the like, nor any conception of development of such polymers.
In damaged portions of body surfaces including skin and hair, structures of peptides, collagen, keratin and the like are disordered or destroyed, and there are many free amino groups, free carboxyl groups and the like derived from the aforementioned disorder or destruction. Further, the structures of the aforementioned polymers are characterized by a backbone hydrocarbon and amino acid residues contained in its side chains. Therefore, it is estimated that such amino acid residues in the polymers are attached to the free amino groups, free carboxyl groups etc. by affinity so that the body surface conditions should be brought toward better conditions, and the body surfaces should be protected or improved by the polymers adsorbed on the damaged portions.
On the other hand, while there have been used anti-bacterial agents, protection of damaged portions from external stimuli with bandages and the like as conventional approaches for protection or improvement of body surfaces, they all do not act on the structures of the body surfaces themselves. That is, the aforementioned function for restoring the structures of body surfaces, which is estimated to be possessed by the polymers, has never been used in the conventional approaches. Therefore, in order to investigate this function, it is necessary to quantitatively label the polymers, and to quantitatively determine their behaviors such as presence and distribution.
As a common technique for labeling compounds, introduction of labeled groups into proper sites of molecules can be mentioned. According to this technique, a defined number of labeled groups can be introduced per molecule, and thus quantitative labeling can be realized. However, because polymer molecules do not have a constant degree of polymerization, a defined amount of labeling groups cannot be introduced into each constituent monomer even by the aforementioned labeling technique. That is, there has been no method for quantitatively labeling polymers so far.
DESCRIPTION OF THE INVENTION
An object of the present invention is to provide a polymer that has, in its partial structure, a group exhibiting affinity for skin, and exhibits beneficial effects on skin functions thanks to the skin affinity group.
Another object of the present invention is to provide a composition containing a polymer that has, in its partial structure, a group exhibiting affinity for skin, and exhibits beneficial effects on skin functions thanks to the skin affinity group.
A further object of the present invention is to provide a method for quantitatively labeling a polymer or a salt thereof.
In view of the situation described above, the inventors of the present invention earnestly conducted studies to seek a polymer exhibiting beneficial effects on skin functions. As a result, they found a polymer or a salt thereof comprising a compound represented by Formula (1) or a salt thereof as a constituent monomer, or having a structure represented by Formula (9) as a partial structure exhibited affinity for skin, and beneficial effects on skins such as protection and improvement of skin. Thus, they accomplished the present invention.
That is, the present invention provides:
(1) a compound represented by Formula (1):
wherein R1, R2 and R3 each independently represent hydrogen atom, an alkyl group, an alkoxyl group, or an alkylamino group; R4 represents an amino acid residue, a polyamine residue, or an aminoalcohol residue; and X represents oxygen atom or a group represented as NH, or a salt thereof;
(2) the compound according to the above (1), wherein the compound represented by Formula (1) is a compound represented by the following Formula (2);
wherein R5 represents hydrogen atom or methyl group, R6 represents an amino acid residue, a polyamine residue, or an aminoalcohol residue; and Y represents oxygen atom or a group represented as NH;
(3) the compound according to the above (1) or (2), wherein the compound represented by Formula (1) is a compound represented by any one of Formulae (3) to (8);
(4) a polymer which contains the compound according to any one of the above (1) to (3) as a constituent monomer, or a salt thereof;
(5) a polymer which has a partial structure represented by Formula (9):
wherein R1, R2 and R3 each independently represent hydrogen atom, an alkyl group, an alkoxyl group, or an alkylamino group; R4 represents an amino acid residue, a polyamine residue, or an aminoalcohol residue; and X represents oxygen atom or a group represented as NH, or a salt thereof;
(6) the polymer according to the above (5), wherein the partial structure represented by Formula (9) is a partial structure represented by Formula (10):
wherein R5 represents hydrogen atom or methyl group, R6 represents an amino acid residue, a polyamine residue, or an aminoalcohol residue; and Y represents oxygen atom or a group represented as NH;
(7) the polymer according to the above (5) or (6), wherein the partial structure represented by Formula (10) is one or more partial structures selected from partial structures represented by any one of Formulae (11) to (17);
(8) the polymer according to any one of the above (4) to (7), wherein molecular weight of the polymer is 5000-1,000,000;
(9) a method for producing of the polymer according to any one of the above (4) to (8), wherein a compound represented by Formula (1) or a salt there
Hattori Takao
Ichinomiya Satoshi
Kitada Yoshio
Kuroda Hideo
Otiai Michi
Knobbe Martens Olson & Bear LLP
Pezzuto Helen L.
Pola Chemical Industries Inc.
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