Compound of stemphones and production thereof

Details Compound of stemphones and production thereof Compound of stemphones and production thereof

2011-07-19

2011-07-19

Saucier, Sandy (Department: 1651)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C435S125000, C435S170000, C435S256100

Reexamination Certificate

active

07982057

ABSTRACT:
The present invention relates to novel compound of stemphones obtained by culturing microorganism belonging to genusAspergillusand having ability to produce compound of stemphones selected from the group consisting of stemphone D substance, stemphone E substance, stemphone E1 substance, stemphone E2 substance, stemphone E3 substance and stemphone F substance, accumulating the compound of stemphones in the cultured mass, and isolating the compound of stemphones from the cultured mass. Since the obtained compound has enhancing activity for imipenem and activity for reducing cytotoxicity, it can be expected to be useful as lead compounds for combination remedy for methicillin resistantStaphylococcus aureus(MRSA) infection.

REFERENCES:
patent: 5879683 (1999-03-01), Hamilton-Miller
patent: 9-509677 (1997-09-01), None
Miller, “Experiment 14, Nitrosoguanidine Mutagenesis”, Experiments in Molecular Genetics, Cold Spring Harbor: New York, 1972.
Koyama et al. J. Antibiotics (Nov. 2005) 58(11): 695-703.
Moubasher, M.H. Bullein of the Faculty of Science, Assiut Univerisity, D; Botany (1999) 28(2): 305-321.
C. Huber et al., “Stemphone, A New Type of Natural Quinone”, Tetrahedron Letters, 1974, vol. 29, pp. 2545-2548.
International Search Report of PCT/JP2006/305625, date of mailing Apr. 18, 2006.

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