Compound, N-butyl-deoxynojirimycin-6-phosphate

Details Compound, N-butyl-deoxynojirimycin-6-phosphate Compound, N-butyl-deoxynojirimycin-6-phosphate

1991-04-12

1992-04-07

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

435131, C07F 959, C12P 900

Patent

active

051030080

ABSTRACT:
A method is provided for converting therapeutic glycosidase inhibitors to novel prodrugs by phosphorylation of a free hydroxyl group on the molecule to substantially reduce the glycosidase inhibitory activity without thereby substantially reducing the therapeutic activity.

REFERENCES:
patent: 4065562 (1977-12-01), Ohata et al.
patent: 4182767 (1980-01-01), Murai et al.
patent: 4847244 (1989-07-01), Rideout et al.
patent: 4849430 (1989-07-01), Fleet et al.
Fleet et al., FEBS Lett. 237, 128-132 (1988).
Karpas et al., Proc. Natl. Acad. Sci. USA 85, 9229-9233 (1988).
Drueckhammer and Wong, J. Org. Chem. 50, 5912-5913 (1985).
Al-Nakib et al., J. Antimicrobiol. Chemother. 20, 887-892 (1987).
Phillpotts et al., J. Antimicrobial Chemother. 14, 403-409 (1984).
Kim and Raushel, Biochemistry 27, 7328-7332 (1988).
Stanek et al., The Monosaccharides, Academic Press, 1963, pp. 229-236.

Affiliated with

Also associated with

Rating

Compound, N-butyl-deoxynojirimycin-6-phosphate does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compound, N-butyl-deoxynojirimycin-6-phosphate, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compound, N-butyl-deoxynojirimycin-6-phosphate will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1896474