Compound-loaded liposomes and methods for their preparation

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

264 41, 264 43, A61K 9127

Patent

active

061104914

ABSTRACT:
A liposome composition containing encapsulated compound in stable precipitated form, and a method for producing the composition, are disclosed. The concentration of precipitated compound within the liposomes is severalfold higher than that in the bulk medium, and the concentration of compound within the liposomes is not reduced in the presence of a proton or alkali metal-ion ionophore added to the suspension.

REFERENCES:
patent: 4946683 (1990-08-01), Forssen
Haran et al., 1151 Biochimica et Biophysica Acta. 201 (1993).
Bally, M., et al., Biochim. Biophys. Acta 812:66-76 (1985).
Barenholz, C., and Haran, G., Chem. Abstr. 114: 12199g (1988).
Carmichael, et al., Cancer Res. 47:936-942 (1987).
Gabizon, A., et al., J. Liposome Res. 1:123-135 (1988-89).
Haran, G., et al., Biochim. Biophys. Acta 1151:201-215 (1993).
Lasic, D.D., et al., Biochim. Biophys. Acta 1239: 145-156 (1995).
Lasic, DD, Liposomes: From Physics to Applications 315-317 (Elsevier 1993).
Maier, et al., Chem. Phys. Lipids 40:333-345 (1986).
Mayer, et al., Biochim. Biophys. Acta 816:294-302 (1985).
Mayer, et al., Biochim. Biophys. Acta 857:123-126 (1986).
Nichols and Deamer, D., Biochim. Biophys. Acta 455:269-171 (1976).
Schwendener, Cancer Drug Delivery 3:123-129 (1986).
Schwendener, et al., Onkologie 10:232-239 (1987).
Straubinger, R.M., et al., Biochemistry 29:4929-4939 (1990).
Szoka, F.C., Jr., and Papahadjopoulos, D., Proc. Natl. Acad. Sci. USA 75:4194-4198 (1978).
Zhu, et al., 39 Cancer Chemother Pharmacol 138 (1996).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Compound-loaded liposomes and methods for their preparation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compound-loaded liposomes and methods for their preparation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compound-loaded liposomes and methods for their preparation will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1246923

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.