Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1989-09-05
1992-05-12
Chan, Christina
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514821, 514929, 530317, 530323, 530800, 435 711, 435171, 435911, A61K 3702, C07K 750, C07K 754, C07K 1102
Patent
active
051128071
ABSTRACT:
A new compound, which we have named "Leualacin" has the formula (I): ##STR1## and may be prepared by cultivation of a microorganism of the genus Hapsidospora, especially Hapsidospora irregularis. The compound may be used for the treatment and prophylaxis of cardiovascular diseases and disorders, especially hypertension.
REFERENCES:
patent: 4285857 (1981-08-01), Chipens et al.
Helms et al., J. Org. Chem. vol. 53, pp. 1298-1307 (1988).
Chemical Abstracts, Stasch et al., Dec. 7, 1987, vol. 107, No. 23 p. 28, col. 1, abstract-no. 211 620t & J. Hypertens, 1986 "Effect on hypertension cardiac hypertrophy and atrial natriuretic peptides of treatment with nitrendipine in SHR".
Chemical Abstracts, Helms et al, Apr. 11, 1988, vol. 108, No. 15, p. 414, col. 2, Abstract No. 128 158y & J. Org. Chem. 1988, 53(6) 1298-307 "Scytonemin A. and novel calcium antagonist from a blue-green alga".
Chemical Abstracts, Smolen et al, Dec. 3, 1984, vol. 101, No. 23, vol. 101, p. 410, col. 1, abstract-no. 208 214j & J. Lab. Clin. Med. 1984, "Lag period for superoxide anion generation and lysosomal enzyme release from human neutrophils: effects of calcium antagonists and anion channel blockers".
Furuya Kouhei
Hamano Kiyoshi
Kagasaki Takeshi
Kinoshita Takeshi
Miyamoto Masaaki
Chan Christina
Sankyo Company Limited
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