Compound inhibiting dipeptidyl peptidase IV

Details Compound inhibiting dipeptidyl peptidase IV Compound inhibiting dipeptidyl peptidase IV

2008-03-18

2008-03-18

Anderson, Rebecca (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S200000, C548S469000

Reexamination Certificate

active

10541108

ABSTRACT:
A dipeptidyl peptidase IV inhibitor which is satisfactory in respect of activity, stability and safety and has an excellent action as a pharmaceutical agent. A compound represented by the following general formula or a pharmaceutically acceptable salt thereof:wherein R1and R2each represents hydrogen, an optionally substituted C1-6 alkyl group, or —COOR5whereupon R5represents hydrogen or an optionally substituted C1-6 alkyl group, or R1, R2, and a carbon atom together represent a 3- to 6-membered cycloalkyl group, R3represents hydrogen or an optionally substituted C6-10 aryl group, R4represents a hydrogen or a cyano group, D represents —CONR6-, —CO— or —NR6CO—, R6represents hydrogen or an optionally substituted C1-6 alkyl group, E represents —(CH2)m— whereupon m is 1 to 3, —CH2OCH2—, or —SCH2—, n is 0 to 3, and A represents an optionally substituted bicyclic heterocyclic group or bicyclic hydrocarbon group.

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Lupus erythematosus [online], [retrieved on Dec. 28, 2006]. Retrieved from the Internet, URL; http://en.wikipedia.org/wiki/Lupus—erythematosus>.
Edwin B. Villhauer, Gary M. Coppola, and Thomas E. Hughes, Novartis Institute for Biomedical Research, Summit, NJ 07901, “Chapter 19. DPP-IV Inhibition and Therapeutic Potential,” Section IV—Immunology, Endocrinology and Metabolic Deseases, Hagmann, Ed., Annual Reports in Medicinal Chemistry-36, pp. 191-200, Copyright © 2001 by Academic Press.

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