Compound including a guanidine group and an unsubstituted tetrap

Details Compound including a guanidine group and an unsubstituted tetrap Compound including a guanidine group and an unsubstituted tetrap

1992-03-20

1993-11-16

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C24100

Patent

active

052625672

ABSTRACT:
A compound useful in the synthesis of peptides containing arginine, and including a guanidine group and an unsubstituted tetraphenylborate ion, and having the formula: ##STR1## wherein A is a hydrogen atom, an amino acid group which is linked by a peptide bond and which may be substituted, a peptide radical which is linked by a peptide bond and which may be substituted, or an aliphatic or aromatic radical effective as a protecting group or an activating group, and wherein Y is an hydroxyl group, a halogen atom, an amino group, an amino acid group which is linked by a peptide bond and which may be substituted, a peptide radical which is linked by a peptide bond and which may be substituted, or an aliphatic or aromatic radical effective as a protecting group or an activating group.

REFERENCES:
patent: 4258152 (1981-03-01), Goldstein et al.
patent: 4725645 (1988-02-01), Auteunis et al.
Greenstein, "Chemistry of the Amino Acids," vol. 1, p. 3, (1961).
"Hackh's Chemical Dictionary," 4th Ed., p. 36 (1972).
Greenstein, "Chemistry of the Amino Acids," vol. 2, pp. 763-776 (1961).
Lehninger, "Biochemistry," 2nd Ed., pp. 71-83 (1970).
Allinger, "Organic Chemistry," 756-762 (1971).
Heavener, G. A., et al., "The Synthesis . . . Thymmoprotein", Pept. Proc. Eur. Pept. Synt., vol. 180, (1984) pp. 465-468.
Diezel, W. et al., "Effect of Splanoprotein . . . ", Exp. Clin. Endocrinol. vol. 87, No. 2, (1986) pp. 215-218.
Ahiko, T., et al., "The Effect of Thymoprotein . . . ", Chem. Pharm. Bull., vol. 28, No. 8, (1980) pp. 2507-2511.
Chemical Abstracts vol. 95, No. 4, Jul. 27, 1981.

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