Compound having anti-HCV activity and process for producing...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

Reexamination Certificate

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Details

C514S239200, C514S231200, C514S256000, C514S274000, C514S252120, C514S327000, C514S349000, C514S357000, C514S438000, C514S625000, C562S450000, C544S398000, C544S168000, C544S316000, C544S335000, C546S335000, C546S300000, C546S216000, C546S339000, C546S334000, C548S255000, C549S077000, C552S008000

Reexamination Certificate

active

10563089

ABSTRACT:
The object of the present invention is to provide a compound useful for the prevention and treatment of viral infectious diseases, and particularly liver diseases caused by HCV infection due to its having a high degree of replication inhibitory activity against HCV, its production method, an intermediate compound useful for its production and a pharmaceutical composition containing these compounds, and the present invention relates to a compound represented by the formula (I):(wherein A represents —(CH2)n—, etc.; B represents —(C═O)—, etc.; D represents —(CH2)m—R′, etc.; E represents a hydrogen atom, etc.; G represents —(CH2)p-J, etc.; bond Q represents a single bond or double bond; and R1, R2and R3may be the same or different and each represent a hydrogen atom, etc.), a prodrug thereof or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 07-173123 (1995-07-01), None
patent: 08-502162 (1996-03-01), None
patent: WO 94/18157 (1994-08-01), None
patent: WO 98/56755 (1998-12-01), None
patent: WO 2004/071503 (2004-08-01), None
Mandala et al. Methods of Enzymology 2000, 311, 335-348.
Esumi et al., “Synthesis of Viridiofungin A Trimethyl Ester and Determination of the Absolute Structure of Viridiofungin A,” Tetrahedron Letters, 1998, vol. 39, pp. 877-880.
Lohmann et al., “Replication of Subgenomic Hepatitis C Virus RNAs in a Hepatoma Cell Line,” Science, Jul. 2, 1999, vol. 285, pp. 110-113.
Esumi et al., “Viridiofungin A no Gosei to Zettai Kozo no Kettei, Dai 39 Kai Symposium on the chemistry of natural products,” Symposium papers, 1997, pp. 409-414.
The Chemical Society of Japan, “Dai 4 Han Jikken Kagaku Koza 19 Yuki Gosei I-Tanka Suiso Halogen Kagobutsu-”, Tokyo, MNaruzen Co., Ltd., 1992, ISBN 4-621-03722-6-C3343, pp. 160-165.

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