Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Reexamination Certificate
2008-05-27
2008-05-27
Anderson, Rebecca (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
C514S239200, C514S231200, C514S256000, C514S274000, C514S252120, C514S327000, C514S349000, C514S357000, C514S438000, C514S625000, C562S450000, C544S398000, C544S168000, C544S316000, C544S335000, C546S335000, C546S300000, C546S216000, C546S339000, C546S334000, C548S255000, C549S077000, C552S008000
Reexamination Certificate
active
07378446
ABSTRACT:
The object of the present invention is to provide a compound useful for the prevention and treatment of viral infectious diseases, and particularly liver diseases caused by HCV infection due to its having a high degree of replication inhibitory activity against HCV, its production method, an intermediate compound useful for its production and a pharmaceutical composition containing these compounds, and the present invention relates to a compound represented by the formula (I):(wherein A represents —(CH2)n—, etc.; B represents —(C═O)—, etc.; D represents —(CH2)m—R′, etc.; E represents a hydrogen atom, etc.; G represents —(CH2)p-J, etc.; bond Q represents a single bond or double bond; and R1, R2and R3may be the same or different and each represent a hydrogen atom, etc.), a prodrug thereof or a pharmaceutically acceptable salt thereof.
REFERENCES:
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patent: WO 2004/071503 (2004-08-01), None
Mandala et al. Methods of Enzymology 2000, 311, 335-348.
Esumi et al., “Synthesis of Viridiofungin A Trimethyl Ester and Determination of the Absolute Structure of Viridiofungin A,” Tetrahedron Letters, 1998, vol. 39, pp. 877-880.
Lohmann et al., “Replication of Subgenomic Hepatitis C Virus RNAs in a Hepatoma Cell Line,” Science, Jul. 2, 1999, vol. 285, pp. 110-113.
Esumi et al., “Viridiofungin A no Gosei to Zettai Kozo no Kettei, Dai 39 Kai Symposium on the chemistry of natural products,” Symposium papers, 1997, pp. 409-414.
The Chemical Society of Japan, “Dai 4 Han Jikken Kagaku Koza 19 Yuki Gosei I-Tanka Suiso Halogen Kagobutsu-”, Tokyo, MNaruzen Co., Ltd., 1992, ISBN 4-621-03722-6-C3343, pp. 160-165.
Fukuda Hiroshi
Hayase Tadakatsu
Kawasaki Ken'ichi
Komiyama Susumu
Masubuchi Miyako
Anderson Rebecca
Chugai Seiyaku Kabushiki Kaisha
Foley & Lardner LLP
Nolan Jason M
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