Compound for treatment of cardiac arrhythmia, synthesis, and met

Details Compound for treatment of cardiac arrhythmia, synthesis, and met Compound for treatment of cardiac arrhythmia, synthesis, and met

1993-06-16

1994-11-15

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549467, 549468, A61K 3134, C07D30780, C07D30781

Patent

active

053648803

ABSTRACT:
Described is a novel compound and method, useful for treatment of cardiac arrhythmias, especially useful in patients with congestive heart failure (CHF). A process for synthesizing the novel compound is also described.

REFERENCES:
patent: 4931464 (1990-06-01), Grover et al.
patent: 4962095 (1990-10-01), Grover et al.
patent: 5175187 (1992-12-01), Baligadoo
Sami, Magdi H. (1991) "Sudden Death in Congestive Heart Failure" J. Clin. Pharmacol. 31:1081-1084.
Smith, William McFate (1985) "Epidemiology of Congestive Heart Failure" The American Journal of Cardiology 55:3A-8A.
McKee, Patrick A., William P. Castelli, Patricia M. McNamara, and William B. Kannel (1971) "The Natural History of Congestive Heart Failure: The Framingham Study" The New England Journal of Medicine 285(26):1441-1446.
Goldstein, Sidney (1991) "Identification of Patients at Risk for Sudden Death in Congestive Heart Failure" J. Clin. Pharmacol. 31:1085-1088.
The Cardiac Arrhythmia Suppression Trial (CAST) Investigators (1989) "Preliminary Report: Effect of Encainide and Flecainide on Mortality in a Randomized Trial of Arrhythmia Suppression after Myocardial Infarction" The New England Journal of Medicine 321(6):406-421.
Bigger, J. Thomas (1987) "Why patients with congestive heart failure die: arrhythmias and sudden cardiac death" Circulation 75(suppl IV):28-35.

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