Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1995-01-30
1998-03-31
Peselev, Elli
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 34, 536 64, 536 185, 536 551, A61K 3170, C07H 100, C07H 1500
Patent
active
057338914
ABSTRACT:
A compound of hyaluronic acid and a medicinal ingredient produced by the convalent bonding (preferably amide bonding) of hyaluronic acid and the medicinal ingredient, and a process for preparing the same.
The hyaluronic acid portion is completely decomposed by metabolism in the action region, whereby the medicinal ingredient is gradually and quantitatively released.
REFERENCES:
Migrdichian, Organic Synthesis, vol. 1, (195) p. 49-50.
Chemical Abstracts; vol. 114, No. 5, 1990, Abstract No. 3552OU , Ouchi, et al., "Design of Polysaccharide-5-Flourouracil Conjugates Exhibiting . . . ".
Chemical Abstracts; vol. 108, No. 24, 1988, Abstracts No. 210111m, Cera et. al., "Anthracycline Antibiotics Supported on Water-Soluble Polysaccharides".
Journal of Cell Science;"CD44: The Hyaluronan Receptor: pp. 293-298; 1992; Charles Underhill.
Advanceds Drug Delivery Review; "Clearence of Hyaluronan From the Circulation" pp. 221-241; 1991; Lena Lebel.
Cell; vol. 65; pp. 13-24; 1991; "A New Variant Of Glycoprotein CD44 Confers Metastatic Potential To Rat Carcinoma Cells; U. Gunthert, et al.
The Journal Of Cell Biology; vol. 116, No 4, pp. 1055-1062; 2.92; "The Hyaluronan Receptor (CD44) Participates In The Uptake And . . . ; M. Cully, et al.
International Journal of Macromol.; 198, vol. 10,; pp. 66-74; "Anthracycline Antibiotics Supported On Water-Soluble Polysaccharides: Synthesis And Physicochemical Characterization"; C. Cera, et al.
International Symposium; Delivery of Protein Drugs-The Next 10 Years; Sep. 2, 1993; K. Akima et al; "Evaluation of Antitumor Activities of Hyaluronate Binding Antitumor Drug-Synthesis, Characterization and Antitumor Activities".
84th Annual Mtg., American Association Of Cancer Research; Mar. 1993; vol. 34; pp. 33-36, 61, 68, 71, 91, and 93.
Cancer Research; vol. 54, pp. 422-426, Jan. 15, 1994; "Potential Use Of Soluble CD44 In Serum As Indicator Of Tumor Burden and Metastasis In Patient With Gastic or Colon Cancer; Y. Guo, et al.
Cancer Cells, Sep. 1991, vol. 3, No. 9, pp. 347-350; "The Transmembrane Hyaluronate Receptor (CD44) :Multiple Functions, Multiple Forms; B. Haynes, et al.
Akima Kazuo
Iwata Yuhei
Matsuo Kayoko
Watari Nobutoshi
Peselev Elli
Shiseido Co. Ltd.
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