Chemistry: analytical and immunological testing – Biospecific ligand binding assay
Reexamination Certificate
2005-08-22
2008-08-12
Russel, Jeffrey E (Department: 1654)
Chemistry: analytical and immunological testing
Biospecific ligand binding assay
Reexamination Certificate
active
07410806
ABSTRACT:
The invention relates to a compound suitable for inhibiting the influx of polymorphonuclear leukocytes (PMNs) into a tissue involved in a chronic inflammatory disease. The compound according to the invention is capable of forming a complex with N-acetyl-Pro-Gly-Pro. The invention also relates to a method of selecting such a compound, a pharmaceutical composition and an application of the compound.
REFERENCES:
patent: 5932217 (1999-08-01), Tuomanen et al.
patent: 6013674 (2000-01-01), Morin et al.
patent: 6310041 (2001-10-01), Haddox et al.
patent: 6489300 (2002-12-01), Thorsett et al.
patent: 2001/0006656 (2001-07-01), Harlan et al.
patent: 2002/0172679 (2002-11-01), Ringler et al.
Haddox et al., “Bioactivity of Peptide Analogs of the Neutrophil Chemoattractant N-Acetyl-Proline-Glycine-Proline.” Investigative Ophthalmology and Visual Science. 40(10):2427-9, Sep. 1999.
Pfister et al., “Injection of Chemoattractants into Normal Cornea A Model of Inflammation after Alkali Injury.” Investigative Ophthalmology and Visual Science, 39(9):1744-50, Aug. 1998.
Pfister et al., “A Neutrophil Chemoattractant is Released from Cellular and Extracellular Components of the Alkali-Degraded Cornea and Blood.” Investigative Ophthalmology and Visual Science, 37(1):230-7, Jan. 1996.
Blalock et al., “Genetic Origins of Protein Shape and Interaction Rules.” Nature Medicine, 1:876-878, 1995.
Pfister et al., “Identification and Synthesis of Chemotactic Tripeptides from Alkali-Degraded Whole Cornea A Study of N-Acetyl-Proline-Glycine-Proline and N-Methyl-Proline-Glycine-Proline.” Investigative Ophthalmology and Visual Science, 36(7):1306-16, Jun. 1995.
Laskin et al., “Chemotactic Activity of Colalgen-Like Polypeptides for Human Peripheral Blood Neutrophilis.” Journal of Leukocyte Biology, 39(3):255-66, Mar. 1986.
Blalock James Edwin
Haddox Jeffrey Lynn
Nijkamp Franciscus Petrus
Pfister Rosswell Robert
Villain Matteo
Amster Rothstein & Ebenstein LLP
Fornix Biosciences N.V.
Russel Jeffrey E
LandOfFree
Compound for inhibiting the influx of polymorphonuclear... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compound for inhibiting the influx of polymorphonuclear..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compound for inhibiting the influx of polymorphonuclear... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3999725