Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1995-06-06
2000-06-13
O'Sullivan, Peter
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
514494, 514518, 514576, 514577, 514764, 514766, 558 45, 558 46, 562 88, 562 89, 562429, A61K 31185, C07C30935, C07C30932
Patent
active
060750502
ABSTRACT:
This invention pertains to the discovery that condensation polymers of an aldehyde and aromatic sulfonic acids and fractions thereof, such as formaldehyde naphthalenesulfonic acid condensation polymers, can abrogate HIV gp120 binding to CD4, as demonstrated in CD4/gp120 binding assays. In addition to gp120 binding inhibition, the compounds have been shown to inhibit HIV-induced syncytia formation and infectivity of CD+ cells. The use of this compound has been shown to be non-cytotoxic and non-inhibitory to antigen induced T lymphocyte proliferation. Based on these findings, these compounds can be used as a therapeutic agent for the treatment of acquired immunodeficiency syndrome (AIDS), as well as AIDS-related complex (ARC), AIDS-related dementia and non-symptomatic HIV infection. The compounds can also be used to treat blood preparations.
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Taylor, D.L. et al., "Novel Sulphonic Acid Polymers as Inhibitors of HIV Host-Cell Interactions," Abstract PO-B26-2071, IXth International Conference on Aids, Jun. 6-11, 1993.
Tan, Ghee T. et al., "Sulfonic acid polymers are potent inhibitors of HIV-1 induced cytopathogenicity and the reverse transcriptases of both HIV-1 and HIV-2," Biochimica et Biophysica Acta, 1181:183-188 (1993).
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McDonald Kevin W.
Neidhardt Edith A.
Palace Gerard P.
Pallai Peter V.
Patch Raymond J.
O'Sullivan Peter
Procept Inc.
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