Compound FO-1289, process of production with aspergillus and str

Details Compound FO-1289, process of production with aspergillus and str Compound FO-1289, process of production with aspergillus and str

1995-12-04

1998-09-15

Marx, Irene

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

4352541, 435913, 4352561, 546270, C12P 1718, C12N 114

Patent

active

058077219

ABSTRACT:
A FO-1289 substance of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are hydrogen or acyl. A process for the production thereof comprises culturing the novel microorganism Aspergillus sp. FO-1289 FERM BP-4242 in a nutrient medium, accumulating the FO-1289 substance thus produced in the medium, and isolating the FO-1289 substance therefrom. Particular species of the FO-1289 substance comprise FO-1289A, in which R.sub.1, R.sub.2 and R.sub.3 are acetyl and R.sub.4 is hydrogen; FO-1289B, wherein R.sub.1 is propionyl, R.sub.2 and R.sub.3 are acetyl and R.sub.4 is hydrogen; FO-1289C, wherein R.sub.1 and R.sub.3 are acetyl, R.sub.2 is propionyl and R.sub.4 is hydrogen; and FO-1289D, wherein R.sub.1 and R.sub.2 are acetyl, R.sub.3 is propionyl and R.sub.4 is hydrogen.

REFERENCES:
patent: 4231938 (1980-11-01), Monaghan
patent: 5151365 (1992-09-01), Dombrowski
patent: 5250935 (1993-10-01), Cover
"Manufacture of FO-1284 Substance from Aspergillus sp. FO-1289 as Acyl-Coenzyme A : Cholesterol Acyltransferas (ACAT) Inhibitor", Chemical Abstracts, vol. 118, No. 24, Jun. 14, 1993, Columbus, Ohio, Abstract No. 24093b, p. 481, by Satoshi Omura et al.

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