Compound exhibiting antiproliferative activity against cells

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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548146, A61K 31425, C07D27710

Patent

active

053247396

ABSTRACT:
Isomers of a cytotoxic compound isolated and purified from a marine cyanobacterium Lyngbya majuscula are disclosed. The isomers termed Curacin A and Curacin B exhibits substantial biological activity against proliferating cells. The Curacin A and Curacin B isomers appear to be antimitotics. Methods for using the isomers are also disclosed.

REFERENCES:
Jutten et al., Tetrahedron vol. 43 No. 8, pp. 4133-4140 (1987).

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