Compound effective as cerebral insufficiency improver

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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5142328, 514255, 514319, 514324, 544 587, 544145, 544151, 544376, 546196, 546202, 549 16, 549281, 549282, 549299, 549300, 549401, 549403, 560 51, 560 76, 562462, C07D491052, C07D51302, A61K 3154, A61K 31535

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active

051790920

ABSTRACT:
A compound having the formula (I): ##STR1## wherein A is --CH.sub.2 --, --O--, or --S--; R.sup.1 is CH.sub.3 or OCH.sub.3 ; R.sup.2 is hydroxy or carboxy which may be optionally esterized or amidated; R.sup.3 is H or a lower alkyl; and n is 0 or an integer of 1 to 6 or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 4774241 (1988-09-01), Tatsuoka et al.
patent: 5057514 (1991-10-01), Tatsuoka et al.
Ginsberg et al. Cerebrovascular Diseases (Raven Press, New York, 1989) pp. 181-222.
Albert Wauquier et al., "R 58 735: A New Antihypoxic Drug with Anticonvulsant Properties and Possible Effects on Cognitive Functions," Drug Development Research, 8:373-380 (1986).
The Merck Manual, 1987 pp. 1336-1340.

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