Compound effective as cerebral insufficiency improver

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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549 23, 549406, 514432, A61K 3135, A61K 3138, C07D31104, C07D33506

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active

052927687

ABSTRACT:
A compound having the formula (I): ##STR1## wherein A is --CH.sub.2 --, --O--, or --S--; R.sup.1 is CH.sub.3 or OCH.sub.3 ; R.sup.2 is hydroxy or carboxy which may be optionally esterized or amidated; R.sup.3 is H or a lower alkyl; and n is 0 or an integer of 1 to 6 or a pharmaceutically acceptable salt thereof.

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Rao. et al. Chemical Abstracts, vol. 57, 1962 Abs., 9800 f-i.
Murty, et al. Chemical Abstracts, vol. 66, 1967 Abstract 652395.
Srihari, et al. Chemical Abstracts, vol. 92, 1980 Abstract 41484d.
Albert Wauquier et al, "R 58 735: A New Antihypoxic Drug With Anticonvulsant Properties and Possible Effects on Cognitive Functions," Drug Development Research, 8:373-380 (1986).
The Merck Manual, 1987 pp. 1336-1340.
Vladimir C. Hackinski et al, "Changing Concepts of Vascular Dementia," Cerebrovascular Diseases, Chapters 20-23, pp. 181-222 (1989).

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