Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1995-02-07
1997-08-19
Kight, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
536 221, 536 231, 204155, 20415715, 607 72, A61K 3170
Patent
active
056588925
ABSTRACT:
A method of increasing delivery of a compound from an exterior region to an interior region of a cell without causing substantial lethality to the cell. The method includes the steps of first providing the compound in the exterior region proximal to a membrane of the cell, and then exposing the membrane to a time-dependent impulse transient characterized by a rise time and a magnitude. In this manner, the exposing step temporarily increases the permeability of the membrane, resulting in an increase in the diffusion of the compound from the exterior region to the interior region thereby enhancing the delivery of the compound without causing substantial lethality to the cell.
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Anderson Therese M.
Doukas Apostolos G.
Flotte Thomas J.
McAuliffe Daniel J.
Kight John
Lee Howard C.
The General Hospital Corporation
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