Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism
Reexamination Certificate
2006-03-14
2009-08-18
Kam, Chih-Min (Department: 1656)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving viable micro-organism
C435S007200
Reexamination Certificate
active
07575889
ABSTRACT:
The present invention provides in vitro assays, e.g., FtsZ GTPase assays, and/or in vivo assays and methods of use thereof to identify particular compounds and combinations of compounds that affect microbial cell division. The invention further provides such compounds and compound combinations, including combinations that result in inhibition of cell survival or growth when present together at concentrations below their individual MICs. Certain of the compound combinations display synergism. Certain of the combinations include a compound that inhibits FtsZ GTPase activity and a compound that inhibits cell growth by a mechanism other than inhibition of FtsZ GTPase activity. The present invention further provides pharmaceutical compositions that have anti-microbial activity and methods of treating microbial infections.
REFERENCES:
patent: 5948889 (1999-09-01), de Boer et al.
patent: 5976826 (1999-11-01), Singhvi et al.
patent: 6368838 (2002-04-01), Singhvi et al.
patent: 6559176 (2003-05-01), Bassler et al.
patent: 7011946 (2006-03-01), RayChaudhuri et al.
patent: 2003/0138869 (2003-07-01), RayChaudhuri et al.
patent: 0505023 (1992-09-01), None
patent: 0505023 (1996-08-01), None
patent: WO 01/85664 (2001-11-01), None
U.S. Appl. No. 09/863,141.
U.S. Appl. No. 10/153,268.
U.S. Appl. No. 10/180,384.
Akiyama, Y., et al.,J. Biol. Chem. 271:31196-31201, 1996.
Berge, S. M., et al.,J. Pharmaceutical Sciences, 66: 1-19, 1977.
Breithaupt, H., “The New Antibiotics: Can Novel Anti-bacterial Treatments Combat the Rising Tide of Drug-Resistant Infections?”Nature Biotechnology, 17: 1165, 1997.
Lee, et al.,J. Biol. Chem. 267:1212-1218, 1992.
Movahed, M.R.J.S.C. Med. Assoc. 95: 303, 1999.
Murray, B.,New Engl. J. Med. 330: 1229-1230, 1994.
International Search Report for PCT/US2006/023168, Date of mailing: Apr. 23, 2007.
Written Opinion of International Searching Authority, PCT/US2006/023168, Date of mailing: Apr. 23, 2007.
Kirschner Marc
RayChaudhuri Debrabata
Choate Hall & Stewart LLP
Jarrell Brenda
Kam Chih-Min
Knight Julie Anne
President and Fellows of Harvard College
LandOfFree
Compound combinations for inhibiting cell division and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compound combinations for inhibiting cell division and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compound combinations for inhibiting cell division and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4052406