Compound binding to leukocytes and medicinal composition...

Details Compound binding to leukocytes and medicinal composition... Compound binding to leukocytes and medicinal composition...

2007-05-22

2007-05-22

Lukton, David (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

C530S327000, C530S329000, C530S330000, C514S014800, C514S015800, C514S016700, C514S017400, C435S007100, C427S099300

Reexamination Certificate

active

10528771

ABSTRACT:
A compound that comprises Met-Leu-Phe or Nle-Leu-Phe serving as the leukocyte-binding site of a formyl peptide receptor (FPR), a binding part comprising Ser or Thr that increases the binding ratio to monocytes and lymphocytes in all leukocytes, a group that can be labeled with a radioactive metal or a paramagnetic metal, and spacers binding the three moieties together shows binding properties specific to all leukocytes, i.e., neutrophils, monocytes and lymphocytes both in vivo and in vitro. Owing to this characteristic, this compound is highly useful in SPECT image diagnosis, PET image diagnosis, MRI image diagnosis and the like, for imaging sites of inflammation.

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D.S. Edwards, et al. “RP463: a stabilized technetium-99m complex of a hydrazino nicotinamide derivatized chemotactic peptide for infection imaging.”Bioconjugate Chemistry1999, vol. 10, No. 5, pp. 884-891.
K. Verbeke,, et al.“Influence of the bifunctional chelate on the biological behavior of 99mTc-labeled chemotactic peptide conjugates.”Nuclear Medicine&Biology, 2000, vol. 27, No. 8, pp. 769-779.
Baidoo, K.E., et al.,High-Affinity No-Carrier-Added 99mTc-Labeled Chemotactic Peptides for Studies of Inflammation in Vivo, Bioconjugate Chem. Mar.-Apr.; 9(2): 1998 208-17.
Baidoo, K.E., et al., Bioconjug. Chem. Mar.-Apr.; 9(2): 1998 208-17.

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