Compound and salts thereof which antagonize angiotensin II

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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548132, A61K 31415, C07P27107

Patent

active

053547667

ABSTRACT:
##STR1## Compounds shown by the above formula or salt thereof show a strong angiotensin II antagonistic activity and hypotensive action and CNS activity, and are useful as therapeutic agents of circulatory diseases such as hypertensive diseases and heart diseases (e.g. hypercardia, heart failure, cardiac infarction), strokes, cerebral apoplexy, nephritis, atherosclerosis, Alzheimer's disease, senile dementia, etc.

REFERENCES:
patent: 4880804 (1989-11-01), Carini et al.
patent: 5196444 (1993-03-01), Naka et al.
patent: 5243054 (1993-09-01), Naka et al.

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